Publications by authors named "Nao Bekku"
Article Synopsis
- Cells use exosomes, which are small vesicles released from multivesicular bodies, to communicate with other cells, and recent research links their formation to autophagy, but the exact mechanisms are still unclear.
- A study highlighted that Rubicon, a protein that negatively regulates autophagy, is crucial for the release of exosomes by recruiting another protein, WIPI2d, to enhance their formation.
- The findings also showed that Rubicon plays a significant role in the age-related increase in exosome release in mice and influences the types of microRNAs found in exosomes, which are related to aging and longevity.
Lysosomes are degradative organelles and signaling hubs that maintain cell and tissue homeostasis, and lysosomal dysfunction is implicated in aging and reduced longevity. Lysosomes are frequently damaged, but their repair mechanisms remain unclear. Here, we demonstrate that damaged lysosomal membranes are repaired by microautophagy (a process termed "microlysophagy") and identify key regulators of the first and last steps.
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