Publications by authors named "Nanyang Jia"
Article Synopsis
- Normal cytogenetic acute myeloid leukemia (AML) often has a TCTG insertion in the NPM1 gene that causes mislocalization of the protein NPM1c to the cytoplasm, yet the mechanisms behind its role in AML are not fully understood.
- This study suggests that the mislocalization of NPM1c disrupts the function of CTCF, a protein critical for DNA looping and gene expression regulation, leading to altered gene expression.
- The researchers confirmed that NPM1c interacts with CTCF, causing CTCF to move to the cytoplasm; by blocking this interaction, CTCF can return to the nucleus and regain its function.
