Publications by authors named "Nanu Pal"
Article Synopsis
- The Polycomb Group complex PRC1, through its subunit Polyhomeotic (Ph), represses transcription and modifies chromatin architecture, with its function dependent on the Sterile Alpha Motif (SAM) that promotes polymerization.
- Short oligomers and phase separation are driven by the SAM, with the length of these oligomers influenced by a long disordered linker connecting the SAM to the rest of Ph, particularly affected by substitutions like PHC3L.
- Research employing biochemical assays and molecular dynamics simulations reveals that while SAM-driven phase separation and polymerization are conserved across species, the mechanisms have evolved significantly due to changes in the disordered linker structure.
