Fucoidan suppresses proliferation and epithelial-mesenchymal transition process via Wnt/β-catenin signalling in hemangioma.

Hemangioma is a common benign tumour that usually occurs on the skin of the head and neck, particularly among infants. The current clinical treatment against hemangioma is surgery excision, however, application of drug is a safer and more economical therapy for children suffering from hemangioma. As a natural sulfated polysaccharide rich in brown algae, fucoidan is widely recognized for anti-tumour bioactivity and dosage safety in humans.

Sublingual immunotherapy in mite-sensitized patients with atopic dermatitis: a randomized controlled study.

Introduction: Sublingual immunotherapy (SLIT) has been shown to be efficacious in patients with airway allergic diseases. However, less data have been demonstrated to show the efficacy of SLIT in patients with atopic dermatitis (AD).

Aim: This study is to evaluate, in a randomized controlled study, the effect of SLIT with house dust mite (HDM) in patients with mild-moderate AD.

[A biomechanical study on polyethylene liner cementing into a fixed acetabular shell in revision total hip arthroplasty].

Objective: To evaluate the strength of polyethylene linercement interface when cementing a new liner into a fixed acetabular cup in revision.

Methods: Twenty-five pairs of metal acetabular cups with polyethylene liners were randomly divided into 5 groups: 1 group with standard locking device as control group (group A), other liners were cemented into acetabular cups as 4 experimental groups. According to different intersection angles of metal acetabular cups with polyethylene liners and the polyethylene liners with or without metal ball, the 4 experimental groups were no ball 0 degrees group (group B), 0 degrees group (group C), 10 degrees group (group D), and 20 degrees group (group E), metal acetabular cups intersected with polyethylene liners without metal ball in group B, with metal ball in groups C, D, and E, respectively.

[Detection of the mRNA expression of human angiotensin-converting enzyme 2 as a SARS coronavirus functional receptor in human femoral head].

Objective: To investigate the mRNA expression of severe acute respiratory syndrome-associated coronavirus (SARS-COV) functional receptor, angiotensin-converting enzyme 2 (ACE2), in human femoral head and conjunctiva, and explore the possible entry route of SARS-COV in human femoral head.

Methods: ACE2 mRNA in human femoral head was detected by nested RT-PCR with human beta actin gene as the positive control.

Results: The mRNA of human beta actin gene could be amplified efficiently in all the tissue samples.

Effects of salmon calcitonin on fracture healing in ovariectomized rats.

Objective: To explore the effects of salmon calcitonin on the healing process of osteoporotic fractures in ovariectomized rats.

Methods: We performed this study in The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China, during the period March 2002 to December 2004. We used 120 female adult Wistar rats in this experiment, among which 90 underwent ovariectomy (OVX) and the other 30 had sham-operation.

[The effect of ultra high molecular weight polyethylene particle on the tissues of joint prosthesis].

Objective: To study the effect of the high molecular weight polyethylene on the periprosthetic tissue in vivo as to give some reference to treatment of loosening hip arthroplasty.

Methods: Every lower limb of 20 New Zealand white rabbits was implanted a Co-Cr-Mo plug in femur by intercondylar notch. 15 mg polyethylene particles, dispersed in 1.