Cyclic mechanical stress promotes osteogenic differentiation of periodontal ligament stem cells via KAT2A-mediated succinylation of WDR5.

Orthodontics promotes tooth movement and periodontal reconstruction by regulating osteogenic differentiation and osteoclast resorption. This study aimed to investigate the effect of orthodontic force during orthodontics on osteogenesis of periodontal ligament stem cells (PDLSCs) and the underlying mechanism. Cyclic mechanical stress was applied on PDLSCs, and osteogenic differentiation was analyzed using quantitative real-time polymerase chain reaction, immunoblotting, alkaline phosphatase (ALP) staining, and ALP activity determination.

Hyperoside ameliorates periodontitis in rats by promoting osteogenic differentiation of BMSCs via activation of the NF-κB pathway.

Hyperoside, as an active compound, widely exists in a large number of Chinese herbal medicines and has been reported to possess anti-inflammatory and diuretic properties. However, the effects and underlying mechanisms of hyperoside on periodontitis have not been previously reported. In this study, we found that hyperoside ameliorates symptoms of periodontitis in a rat model, with improvements in alveolar bone resorption, relief of inflammatory infiltration, increase in orderly arrangement of collagen fibers and increase of osteogenic differentiation.