Mussel-inspired "plug-and-play" hydrogel glue for postoperative tumor recurrence and wound infection inhibition.

Currently, clinical tumor resection is faced with two options: open and minimally invasive surgery. Open surgery is easy to completely remove the lesion but is prone to infection, while minimally invasive surgery recovers faster but may cause tumor recurrence. To fill the shortcomings of the two surgical modes and make the choice for tumor resection more effortlessly, we developed a postoperative black phosphorus-Ag nanocomposites-loaded dopamine-modified hyaluronic acid-Pluronic® F127 (BP-Ag@HA-DA-Plu) hydrogel implantation system that can prevent tumor recurrence and wound infection simultaneously.

Multimodal Local Resonators for Low-Frequency Amelioration of Acoustic Black Holes.

Acoustic black holes (ABHs) are effective at suppressing vibrations at high frequencies, but their performance at low frequencies is limited. This paper aims to improve the low-frequency performance of ABH plates through the design of a metamaterial acoustic black hole (MMABH) plate. The MMABH plate consists of a double-layer ABH plate with a set of periodic local resonators installed between the layers.

An injectable hydrogel based on BiSe nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy.

To resolve poor accumulation caused by systemic administration, injectable and responsive hydrogels are the prospective drug delivery systems for localized tumor treatment, owning to negligible invasiveness and accurate administration. Herein, an injectable hydrogel, based on dopamine (DA) crosslinked hyaluronic acid and BiSe nanosheets (NSs) loading with doxorubicin (DOX) coated with polydopamine (BiSe-DOX@PDA), was developed for synergistic chem-photothermal cancer therapy. The ultrathin functional BiSe-DOX@PDA NSs could be responsive to the weak acidic condition and photothermal effect under NIR laser irradiation, achieving controlled release of DOX.

Self-driven nanoprodrug platform with enhanced ferroptosis for synergistic photothermal-IDO immunotherapy.

Insufficient immune stimulation and stubborn immune resistance are the critical factors limiting tumor immunotherapy. Here, we report a multifunctional nanoprodrug platform with self-driven indoximod (IND) release and oxidative stress amplification. The aim is to awaken immune responses and block the indoleamine 2,3-dioxygenase (IDO) pathway through a combination of ferroptosis, photothermal therapy, and immunotherapy.

Actively separated microneedle patch for sustained-release of growth hormone to treat growth hormone deficiency.

Growth hormone deficiency (GHD) has become a serious healthcare burden, and presents a huge impact on the physical and mental health of patients. Here, we developed an actively separated microneedle patch (PAA/NaHCO-Silk MN) based on silk protein for sustained release of recombinant human growth hormone (rhGH). Silk protein, as a friendly carrier material for proteins, could be constructed in mild full-water conditions and ensure the activity of rhGH.

Mussel-Inspired Ligand Clicking and Ion Coordination on 2D Black Phosphorus for Cancer Multimodal Imaging and Therapy.

As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in the inherent instability, while it can be improved by surface modification strategies to a great extent. Considering the existing infirm BP NSs surface modification strategies, A mussels-inspired strong adhesive biomimetic peptide with azide groups for surface modification to increase the stability of BP NSs is synthesized. The azide groups on the peptide can quickly and precisely bind to the targeting ligand through click chemistry, solving the problem of nonspecificity of secondary modification of other mussel-mimicking materials.

pH-Sensitive and Charge-Reversal Polymeric Nanoplatform Enhanced Photothermal/Photodynamic Synergistic Therapy for Breast Cancer.

As reported, breast cancer is one of the most common malignancies in women and has overtaken lung cancer as the most commonly diagnosed cancer worldwide by 2020. Currently, phototherapy is a promising anti-tumor therapy due to its fewer side effects, less invasiveness, and lower cost. However, its application in cancer therapeutics is limited by the incomplete therapeutic effect caused by low drug penetration and monotherapy.

A light-weight periodic plate with embedded acoustic black holes and bandgaps for broadband sound radiation reduction.

Conceiving lightweight structures with low vibration and sound radiation properties is an important topic. The concept of Acoustic Black Hole (ABH) offers new impetus to tackle this problem. Most existing ABH structures are based on simple ABH cells.

Charge-reversal biodegradable MSNs for tumor synergetic chemo/photothermal and visualized therapy.

Given the difficulties of biodegradation of mesoporous silica nanoparticles (NPs), enrichment and penetration of tumor sites, and real-time monitoring of the treatment process, we developed a kind of mannose-doping doxorubicin-loading mesoporous silica nanoparticle (MSN-Man-DOX) and coated by polydopamine-Gd (PDAGd) metal-phenolic networks, as well as modified by poly (2-Ethyl-2-Oxazoline) (PEOz), constructing a novel nanomedicine MSN-Man-DOX@PDA-Gd-PEOz. Its pH-responsive charge reversal, photothermal, biodegradation, drug release, and magnetic resonance imaging (MRI) properties were evaluated in vitro. Cellular uptake, tumor penetration, lysosomal escape properties, as well as cell safety and toxicity of the nanoplatform were investigated through cell experiments.

Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer.

Driven by the lifestyle habits of modern people, such as excessive smoking, drinking, and chewing betel nut and other cancer-causing foods, the incidence of oral cancer has increased sharply and has a trend of becoming younger. Given the current mainstream treatment means of surgical resection will cause serious damage to many oral organs, so that patients lose the ability to chew, speak, and so on, it is urgent to develop new oral cancer treatment methods. Based on the strong killing effect of photothermal therapy on exposed superficial tumors, we developed a pH-responsive charge reversal nanomedicine system for oral cancer which is a kind of classic superficial tumor.

Black phosphorus-based nano-drug delivery systems for cancer treatment: Opportunities and challenges.

In this comment, the opportunities of black phosphorus-based nano-drug delivery systems for cancer treatment are highlighted.Image, graphical abstract.

Applications of Surface Modification Technologies in Nanomedicine for Deep Tumor Penetration.

The impermeable barrier of solid tumors due to the complexity of their components limits the treatment effect of nanomedicine and hinders its clinical translation. Several methods are available to increase the penetrability of nanomedicine, yet they are too complex to be effective, operational, or practical. Surface modification employs the characteristics of direct contact between multiphase surfaces to achieve the most direct and efficient penetration of solid tumors.

Teaching-learning-based optimization of a composite metastructure in the 0-10 kHz broadband sound absorption range.

This paper proposes a strategy to broaden the sound absorption region of porous materials by embedding ribs. The theoretical solution and the numerical simulations of the optimization model show that the composite metastructure exhibits ultra-wide high absorption characteristics and an average sound absorption coefficient of 0.937 in the 0-10 kHz range upon its teaching-learning-based optimization.

Two-dimensional finite-difference time-domain formulation for sound propagation in a temperature-dependent elastomer-fluid medium.

This study focuses on the two-dimensional (2-D) finite-difference time-domain (FDTD) formulations to investigate the acoustic wave propagation in elastomers contained in a fluid region under different thermal conditions. The developed FDTD formulation is based on a direct solution of the time-domain wave equation and the Havriliak-Negami (H-N) dynamic mechanical response of the elastomers. The H-N representation, including double fractional derivative operators, can be accurately transferred from the frequency-domain to the time-domain by using Riemann-Liouville theory and the Grunwald-Letnikov operator for fractional derivative approximations.

Polydopamine-Based "Four-in-One" Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy.

The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy of cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for the dual loading of chemotherapeutic drugs. The hydrophobic anticancer drug docetaxel (DTX) was loaded into the polymeric nanoparticles (NPs) which were fabricated from the star-shaped copolymer CA-PLGA.

pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy.

Synergistic cancer therapy, such as those combining chemotherapeutic and photothermal methods, has stronger treatment effect than that of individual ones. However, it is challenging to efficiently deliver nanocarriers into tumor cells to elevate intracellular drug concentration. Herein, we developed an effective pH-responsive and dual drug co-delivery platform for combined chemo/photothermal therapy.

Design and experimental investigation of V-folded beams with acoustic black hole indentations.

This paper proposes a strategy to broaden complete bandgap attenuating flexural and longitudinal modes, and to shift them to lower frequencies by spatially folding designs. Numerical simulations show that the V-folded acoustic black hole beam exhibits an ultra-wide complete bandgap below 1 kHz due to longitudinal-flexural waveform transformation, and experimental results verify this finding. The proposed folded beams are easy-to-fabricate, of compact dimensions, and exhibit excellent wave attenuation functionality that makes them promising for low-frequency vibration reduction and wave attenuation applications.

Normal incidence sound transmission loss evaluation with a general upstream tube wave decomposition formula.

This study presents a method for measuring the normal incidence sound transmission loss of acoustical materials used in classical piping systems from upstream surface complex reflection coefficient measurements only. Based on the standard transfer function method, the wave field of the upstream tube is further decomposed, and the relationship between the complex reflection coefficient and the twice-transmitted wave is deduced. Similar to the so-called upstream surface impedance (USI) method, two microphone locations and air cavities with several depths are required.

A Versatile Platform Based on Black Phosphorus Nanosheets with Enhanced Stability for Cancer Synergistic Therapy.

Cancer can be effectively treated by photothermal therapy in combination with chemotherapy. Black phosphorus (BP) nanosheets (NSs) have been considered as a promising nanocarrier for synergistic chemo/photothermal therapy. However, the intrinsic instability of bare BP is a great challenge for drug delivery applications.

Complex Young's modulus measurement by incident wave extracting in a thin resonant bar.

This study presents a method for measuring the complex Young's modulus of viscoelastic materials by extracting the incident wave within a thin bar. A Butterworth impulse is generated by an electromagnetic shaker and is employed to excite a bar-like sample. The experimental results prove that the method proposed in this study can determine the Young's modulus at frequencies ranging from 200 to 6500 Hz under atmospheric pressure and room temperature.

TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance.

A nanocarrier system of d-a-tocopheryl polyethylene glycol 1000 succinate (TPGS)-functionalized polydopamine-coated mesoporous silica nanoparticles (NPs) is developed for sustainable and pH-responsive delivery of doxorubicin (DOX) as a model drug for the treatment of drug-resistant nonsmall cell lung cancer. Such nanoparticles are of desired particle size, drug loading, and drug release profile. The surface morphology, surface charge, and surface chemical properties are also successfully characterized by a series of techniques such as transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Brunauer-Emmett-Teller (BET) method, thermal gravimetric analysis (TGA), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FTIR).

Research on bandgaps in two-dimensional phononic crystal with two resonators.

In this paper, the bandgap properties of a two-dimensional phononic crystal with the two resonators is studied and embedded in a homogenous matrix. The resonators are not connected with the matrix but linked with connectors directly. The dispersion relationship, transmission spectra, and displacement fields of the eigenmodes of this phononic crystal are studied with finite-element method.