Research on neural information detecting system measuring neuroelectricity in hippocampus in vivo and dopamine in vitro based on microelectrode array.

Concurrently detecting the electrical activity of neurons and neurotransmitter release signals, will have a great significance in understanding the working mechanism of the brain. This paper describes a neural information detecting system based on microelectrode array(MEA) measuring neuroelectricity in hippocampus in vivo and dopamine(DA) in vitro. The detecting system contains of electrophysiological headstage, electrochemical headstage, microprocessor, electrophysiological signal amplifier, data acquisition module and neural signal analysis software.

Power spectral differences of electrophysiological signals detected at acupuncture points and non-acupuncture points.

In this study, we chose 10 acupoints and non-acupuncture point control groups to see if there are electrical differences between acupoints and non-acupoints. 4 adjacent non-acupoints around each acupoint were chosen as a control group in 400 trials on 10 volunteers aged 23-30 years to characterize the Power Spectral Density of acupoint electrophysiological signals, which means the differences of power and its distribution in frequency. The electrophysiological signals of acupoints and control groups were recorded simultaneously.

A high sensitivity MEA probe for measuring real time rat brain glucose flux.

The mammalian central nervous system (CNS) relies on a constant supply of external glucose for its undisturbed operation. This article presents an implantable Multi-Electrode Array (MEA) probe for brain glucose measurement. The MEA was implemented on Silicon-On-Insulator (SOI) wafer using Micro-Electro-Mechanical-Systems (MEMS) methods.

A novel method to directionally stabilize enzymes together with redox mediators by electrodeposition.

This paper depicts a novel method to directionally stabilize enzymes together with redox mediators by electrodeposition. Chitosan was used as a stabilizing matrix. By electrochemical removal of local H(+), chitosan close to working electrode became locally insoluble, and enzymes and redox mediators in chitosan were stabilized.

Planar microelectrode chip for synchronous simulative neurochemical and neuroelectrial monitoring.

The microfabricated microelectrode arrays on glass substrate combined with homemade multichannel detection system as a powerful tool for synchronous neurochemical and neuroelectrial monitoring was described. The dual-mode (neurochemical and neuroelectrial: simultaneous recording of spikes, and dopamine overflow on the same spatiotemporal scale) recording was carried in PBS buffer. The neurochemical constant potential amperometry was carried at +0.

A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro.

The communication between neurons is inherently electrical and chemical in nature. In situ, simultaneous acquisition for the dual mode signals is important for neuroscience research. In this paper, the concept of dual mode neural microelectrode array (MEA) sensor was proposed, and a low cost thin film MEA chip for in vitro test was fabricated using standard lithography technology.

An ascorbic acid amperometric sensor using over-oxidized polypyrrole and palladium nanoparticles composites.

We constructed a highly responsive ascorbic acid (AA) sensor utilizing over-oxidized polypyrrole (OPPy) and Palladium nanoparticles (PdNPs) composites (OPPy-PdNPs). In the presence of PdNPs, polypyrrole (PPy) was coated on a gold (Au) electrode through cyclic voltammetry (CV) and over-oxidized at a fixed potential in NaOH solution. The PdNPs were characterized using ultraviolet-visible (UV-vis) spectrum and transmission electron microscopy (TEM).