Monocyte CD36 Expression Predicts Disease Activity in Patients With Crohn's Disease.

Crohn's disease (CD) is a chronic intestinal inflammatory disease associated with genetic, environmental, and other unknown factors. Cluster of differentiation 36 (CD36) plays an important role in cancer, inflammation, and metabolic diseases. Although CD36 has recently been implicated in various diseases, its role in CD is still unclear.

Does HLA-DQA1*05 carriage have a greater impact on the outcome of infliximab therapy for isolated small-bowel Crohn's disease?

Carriage of HLA-DQA1*05 is thought to increase the formation of anti-tumour necrosis factor alpha (TNF-α) antibodies, reducing the drug efficacy in Crohn's disease (CD) patients. However, little data are currently available for small-bowel Crohn's disease (SB-CD). A specific assessment of the impact of HLA-DQA1*05 on the clinical response to treatment with infliximab (IFX), a TNF-α antagonists, in SB-CD patients is necessary.

Biomass Hydrogel Electrolytes toward Green and Durable Supercapacitors: Enhancing Flame Retardancy, Low-Temperature Self-Healing, Self-Adhesion, and Long-Term Cycling Stability.

Hydrogels have shown promise as quasi-solid-state electrolytes for flexible supercapacitors but face challenges such as poor self-repair, unstable electrode adhesion, limited temperature range, and flammability. Herein, an all-round green hydrogel electrolyte (silk nanofibers (SNFs)/peach gum polysaccharide (PGP)/borax/glycerol (SPBG)-ZnSO) addresses these issues through dynamic cross-linking of peach gum polysaccharide and silk nanofibers with borax, integrating varieties of key property including high water retention, broad temperature tolerance (-20 to 90 °C), excellent self-adhesion (60.7 kPa for carbon cloth electrodes), satisfactory flame retardancy (limited oxygen index of 51%), low-temperature self-healing (-20 °C), and good ionic conductivity (7.

Fire-resistant and low-temperature self-healing bio-based hydrogel electrolytes based on peach gum polysaccharide/sisal nanofibers for flexible supercapacitors.

The introduction of flame retardancy and low-temperature self-healing capacities in hydrogel electrolytes are crucial for promoting the cycle stability and durability of the flexible supercapacitors in extreme environments. Herein, biomass-based dual-network hydrogel electrolyte (named PSBGL), was synthesized with borax crosslinked peach gum polysaccharide/sisal nanofibers composite, and its application in flexible supercapacitors was also investigated in detail. The dynamic cross-linking of the dual-network endows the PSBGL with excellent self-healing performance, enabling ultrafast self-healing within seconds at both room temperature and extreme low temperatures.

The role of cytolethal distending toxin in Glaesserella parasuis JS0135 strain infection: Cytotoxicity, phagocytic resistance and pathogenicity.

Glaesserella parasuis is an important porcine pathogen that commonly colonizes the upper respiratory tract of pigs and is prone to causing Glässer's disease under complex conditions. As yet, the disease has led to serious economic losses to the swine industry worldwide. Studies so far have found that several virulence factors are associated with the pathogenicity of G.

Nonstoichiometry-Induced Self-Activated Phosphors for Dynamic Anti-counterfeiting Applications.

Optical signals with distinctive properties, such as contactless, fast response, and high identification, are harnessed to realize advanced anti-counterfeiting. However, the simultaneous attainment of multi-color, -temporal, and -modal luminescence performance remains a compelling and imperative pursuit. In our work, a temperature/photon-responded dynamic self-activated luminescence originating from nonstoichiometric ZnGeO is developed with the modulation of intrinsic defects.

Effect of enzymatic hydrolysis of arabinoxylan on the quality of frozen dough during the subfreezing process.

Background: The objective of this investigation was to examine the impact of enzymatic hydrolysis of arabinoxylan (AX) on frozen dough quality under subfreezing conditions. The dough was subjected to freezing at -40 °C for 2 h and then stored at -9, -12, and -18 °C for 15 days. The water loss, freezable water content, water migration, and microstructure of the dough were measured.

EBV abortive lytic cycle promotes nasopharyngeal carcinoma progression through recruiting monocytes and regulating their directed differentiation.

Epstein-Barr virus (EBV) is associated with several types of human cancer including nasopharyngeal carcinoma (NPC). The activation of EBV to the lytic cycle has been observed in advanced NPC and is believed to contribute to late-stage NPC development. However, how EBV lytic cycle promotes NPC progression remains elusive.

Integration of MnO Nanosheets with Pd Nanoparticles for Efficient CO Electroreduction to Methanol in Membrane Electrode Assembly Electrolyzers.

It remains a challenge to design a catalyst with high selectivity at a large current density toward CO electrocatalytic reduction (COER) to a single C liquid product of methanol. Here, we report the design of a catalyst by integrating MnO nanosheets with Pd nanoparticles to address this challenge, which can be implemented in membrane electrode assembly (MEA) electrolyzers for the conversion of COER to methanol. Such a strategy modifies the electronic structure of the catalyst and provides additional active sites, favoring the formation of key reaction intermediates and their successive evolution into methanol.

Occurrence of 8 trace elements in Rhizoma Cibotii from China and exposure assessment.

The contamination of trace elements in Chinese edible herbs has attracted worldwide concern over the world. The objective of the present study was to investigate the occurrence and exposure assessment of eight trace elements in Rhizoma Cibotii from China. For this purpose, the method of inductively coupled plasma mass spectrometry was employed to detect the contamination levels of target trace elements in 58 Rhizoma Cibotii samples.

Differential expression of zinc finger CCHC-type superfamily proteins in thyroid carcinoma and their associations with tumor immunity.

Background: The zinc-finger CCHC-type (ZCCHC) superfamily proteins are characterized by the shared sequence CX2-CX4-HX4-C and thought to own high affinity to single-stranded nucleic acids, particularly RNAs. In humans, a total of 24 ZCCHC proteins have been annotated in the HUGO Gene Nomenclature Committee (HGNC, https://www.genenames.

Erasable, Rewritable, and Reprogrammable Dual Information Encryption Based on Photoluminescent Supramolecular Host-Guest Recognition and Hydrogel Shape Memory.

Information encryption technologies are very important for security, health, commodity, and communications, etc. Novel information encryption mechanisms and materials are desired to achieve multimode and reprogrammable encryption. Here, a supramolecular strategy is demonstrated to achieve multimodal, erasable, reprogrammable, and reusable information encryption by reversibly modulating fluorescence.

A new lysosome-targeted fluorescent probe for hydrogen peroxide based on a benzothiazole derivative.

As an important member of reactive oxygen species, hydrogen peroxide (HO) plays a key role in oxidative stress and cell signaling. Abnormal levels of HO in lysosomes can induce damage or even loss of lysosomal function, leading to certain diseases. Therefore, real-time monitoring of HO in lysosomes is very important.

Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.

Kaposi's sarcoma-associated herpesvirus (KSHV) has been implicated in the pathogenesis of Kaposi's sarcoma (KS) and other malignancies. The cellular origin of KS has been suggested to be either mesenchymal stem cells (MSCs) or endothelial cells. However, receptor(s) for KSHV to infect MSCs remains unknown.

Time-Frequency Characteristics and Evolution Law of Acoustic Emission Signals during the Deformation and Failure of Deformed Coal.

The research on the time-frequency characteristics and evolution law of acoustic emission (AE) signals during deformed coal failure is more conducive to understand the damage mechanism of coal. In this study, the experiments of AE monitoring during the intact and deformed coal failure were first conducted under loading axial stress and unloading confining stress conditions. Based on the evolution characteristics of volume strain and AE event rate, the damage process of coal was divided into three stages: nonfracture development stage, stable development stage of fracture, and unstable development stage of fracture.

Printable Thermochromic Hydrogel-Based Smart Window for All-Weather Building Temperature Regulation in Diverse Climates.

Thermochromic smart windows are widely developed to modulate building energy exchange to save building energy consumption. However, most smart windows have fixed working temperatures, moderate energy-saving efficiency, and are not suitable for diverse (cold and hot) climates. Here smart windows with strong temperature modulation over a broad range of hydrogels with adjustable transition temperatures for all-weather building temperature regulation in different climates are reported.

Bidirectional motivated bimodal isothermal strand displacement amplifier with a table tennis-like movement for the ultrasensitive fluorescent and colorimetric detection of depression-related microRNA.

An increasing number of studies have highlighted the potential of microRNAs (miRNAs) as physiological indicators of major depressive disorder (MDD). Herein, we developed a bidirectional-motivated bimodal isothermal strand displacement amplifier (BB-ISDA) for the ultrasensitive fluorescent and colorimetric detection of MDD-related miRNA-132. In the BB-ISDA system, a pair of functionalized hairpin probes (HP1 and HP2) with nicking recognition sites are designed to recognize target miRNA.

A naphthalimide-based and Golgi-targetable fluorescence probe for quantifying hypochlorous acid.

The Golgi apparatus (GA) is a vital organelle in biological systems and excess reactive oxygen species (ROS) is produced during stress in the Golgi apparatus. Hypochlorous acid (HOCl) is a significant reactive oxygen species and has strong oxidative and antibacterial activity, but excessive secretion of hypochlorous acid can affect Golgi structure or function abnormally, it will lead to a series of diseases including Alzheimer's disease, neurodegenerative diseases, autoimmune diseases, and Parkinson's disease. In present work, a novel fluorescent probe for Golgi localization utilizing naphthalimide derivatives was constructed to detect hypochlorous acid.

Shaggy regulates tissue growth through Hippo pathway in Drosophila.

The evolutionarily conserved Hippo pathway coordinates cell proliferation, differentiation and apoptosis to regulate organ growth and tumorigenesis. Hippo signaling activity is tightly controlled by various upstream signals including growth factors and cell polarity, but the full extent to which the pathway is regulated during development remains to be resolved. Here, we report the identification of Shaggy, the homolog of mammalian Gsk3β, as a novel regulator of the Hippo pathway in Drosophila.

Rhodamine-Based Fluorescent Probe for Highly Selective Determination of Hg.

The determination of mercuric ions (Hg) in environmental and biological samples has attracted the attention of researchers lately. In the present work, a novel turn-on Hg fluorescent probe utilizing a rhodamine derivative had been constructed and prepared. The probe could highly sensitively and selectively sense Hg.

Over 70 % Faradaic Efficiency for CO Electroreduction to Ethanol Enabled by Potassium Dopant-Tuned Interaction between Copper Sites and Intermediates.

It is highly desired yet challenging to steer the CO electroreduction reaction (CO ER) toward ethanol with high selectivity, for which the evolution of reaction intermediates on catalytically active sites holds the key. Herein, we report that K doping in Cu Se nanosheets array on Cu foam serves as a versatile way to tune the interaction between Cu sites and reaction intermediates in CO ER, enabling highly selective production of ethanol. As revealed by characterization and simulation, the electron transfer from K to Se can stabilize Cu species which facilitate the adsorption of linear *CO and bridge *CO intermediates to promote C-C coupling during CO ER.

Comparison of peripherally inserted central catheters (PICCs) versus totally implantable venous-access ports in pediatric oncology patients, a single center study.

To compare the efficacy of peripherally inserted central catheters (PICCs) and totally implantable venous-access ports (TIVAPs) for chemotherapy of pediatric patients with malignant tumors. A total of 96 children with malignant tumors who received catheterization of PICCs or TIVAPs for chemotherapy from May 2020 to May 2021 in Department of Pediatric Oncology of Qilu Hospital of Shandong University were selected. Then, the pathological features of disease, the age of children, the indwelling time, the incidence of postoperative complications, and the satisfaction degree were compared between the two groups.