Publications by authors named "Nannan Zhangning"
Article Synopsis
- NMOSD (Neuromyelitis optica spectrum disorders) often coexists with connective tissue disorders (CTD), and this study aimed to compare their features in patients with and without CTD.
- Patients (18 with CTD and 39 without) were assessed for clinical, laboratory, and MRI characteristics, revealing that NMOSD with CTD showed some significant differences.
- Key findings included higher serum IgG and longer spinal cord lesions in NMOSD patients with CTD, along with different MRI features like more T1 hypointensity and T2 bright spotty lesions, while most other characteristics remained similar.
Objective: To determine the effect of a lower dose of rituximab in depleting B lymphocytes, maintaining low B-cell counts, and relapse in patients with neuromyelitis optica (NMO) and NMO spectrum disorders.
Methods: We treated 5 Chinese patients with deteriorating NMO and NMO spectrum disorders with a 100-mg IV infusion of rituximab once a week for 3 consecutive weeks, followed by additional infusion of the same dosage depending on circulating B-cell repopulation.
Results: This reduced dosage of rituximab was sufficient to deplete B cells and maintain low B-cell counts.