Functionalized Biomass Carbon-Based Adsorbent for Simultaneous Removal of Pb and MB in Wastewater.

It is of great significance to realize the sustainable development of the environment to synthesize functional materials by value-added utilization of waste resources. Herein, a composite material of polyacrylic acid/lignosulfonate sodium/cotton biochar (PAA/LS/BC) was successfully prepared by grafting polyacrylic acid with functionalized waste cotton biochar and lignosulfonate sodium. The obtained absorbent showed prominent capture ability toward Pb and methylene blue (MB) with capture characteristics of the pseudo-second-order model and Langmuir isotherm model.

Self-assembling of versatile SiN@SiO nanofibre sponges by direct nitridation of photovoltaic silicon waste.

Solar cells based on crystalline silicon wafers have dominated the global photovoltaic market for many years. Unfortunately, a large amount of photovoltaic silicon waste (PSW) also was produced during the process of cutting silicon ingot into silicon wafer. The improperly discarded PSW will bring about serious environmental hazardous problems, so it is highly necessary to safely and effectively recover and utilize PSW.

Assessing the health impacts attributable to PM and ozone pollution in 338 Chinese cities from 2015 to 2020.

China has effectively reduced the fine particulate (PM) pollution from 2015 to 2020. Ozone pollution and related health impacts have become severe contemporaneously. The coordinated control of PM and ozone is becoming a new issue for China's air pollution control.

Plasma cytokine changes and its clinical significance in intracranial infection secondary to traumatic brain injury.

Objective: This study aimed to investigate the plasma cytokine changes and its clinical significance in intracranial infection secondary to traumatic brain injury.

Methods: A total of 60 cases with intracranial infection secondary to traumatic brain injury admitted to our hospital from January 2017 to December 2019 were selected as the research objects, of whom, 24 cases with mild infection, 20 with moderate infection, and 16 with severe infection. Another 60 cases without intracranial infection secondary to traumatic brain injury during the same period were selected as the uninfected group.

Retraction: Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from .

Retraction of 'Chemical synthesis and antigenic activity of a phosphatidylinositol mannoside epitope from Mycobacterium tuberculosis' by Shi-Yuan Zhao et al., Chem. Commun.

hAECs and their exosomes improve cardiac function after acute myocardial infarction in rats.

Background: Human amniotic epithelial cells (hAECs) are seed cells used to treat acute myocardial infarction (AMI), but their mechanism remains unclear.

Methods: We cultured hAECs and extracted exosomes from culture supernatants. Next, we established a stable AMI model in rats and treated them with hAECs, exosomes, or PBS.

Recent advances in near-infrared II imaging technology for biological detection.

Molecular imaging technology enables us to observe the physiological or pathological processes in living tissue at the molecular level to accurately diagnose diseases at an early stage. Optical imaging can be employed to achieve the dynamic monitoring of tissue and pathological processes and has promising applications in biomedicine. The traditional first near-infrared (NIR-I) window (NIR-I, range from 700 to 900 nm) imaging technique has been available for more than two decades and has been extensively utilized in clinical diagnosis, treatment and scientific research.

An Overview of Systematic Reviews of Acupuncture for Infertile Women Undergoing Fertilization and Embryo Transfer.

Currently, more and more subfertility couples are opting for combined acupuncture to improve the success rate of fertilization and embryo transfer (IVF-ET). However, the efficacy and safety of acupuncture in IVF-ET is still highly controversial. The purpose of this overview is to summarize evidence of essential outcomes of systematic reviews (SRs) of acupuncture in IVF-ET and evaluate their methodological quality.

DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells.

ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancers. However, the underlying mechanisms remain largely unknown. In this study, we investigated the inhibitory effects of ADAMTS9 on gastric cancer (GC) cells.

Effects of ε-polylysine and rosemary extract on quality attributes and microbial communities in vacuum-packaged large yellow croaker () during ice storage.

The effects of vacuum package combined with 0.1% ε-polylysine and 0.2% rosemary extract (V + RP) on the quality attributes and microbial communities of large yellow croaker () during ice storage were investigated.

RRM2 silencing suppresses malignant phenotype and enhances radiosensitivity via activating cGAS/STING signaling pathway in lung adenocarcinoma.

Background: As one of the most common malignancy, lung adenocarcinoma (LUAD) is characterized by low 5-year survival rate. This research aimed to investigate the effects of ribonucleotide reductase regulatory subunit M2 (RRM2) on malignant biological behaviors and activation of cGAS/STING pathway. We also explored the synergistic sensitization mechanisms of RRM2 and radiotherapy.

Genome-wide identification and transcriptional analysis of ammonium transporters in Saccharum.

Ammonium transporters (AMTs) are plasma membrane proteins that exclusively transport ammonium/ammonia. It is essential for the nitrogen demand of plantsby AMT-mediated acquisition of ammonium from soils. The molecular characteristics and evolutionary history of AMTs in Saccharum spp.

The Dynamic Response of Nitrogen Transformation to the Dissolved Oxygen Variations in the Simulated Biofilm Reactor.

Lab-scale simulated biofilm reactors, including aerated reactors disturbed by short-term aeration interruption (AE-D) and non-aerated reactors disturbed by short-term aeration (AN-D), were established to study the stable-state (SS) formation and recovery after disturbance for nitrogen transformation in terms of dissolved oxygen (DO), removal efficiency (RE) of NH-N and NO-N and activity of key nitrogen-cycle functional genes A and S (RNA level abundance, per ball). SS formation and recovery of DO were completed in 0.56-7.

Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC.

Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the current MR contrast agents are still facing challenges in the early diagnosis of HCC due to their relatively low sensitivity and biosafety.

Hierarchical iron molybdate nanostructure array for efficient water oxidation through optimizing electron density.

The water oxidation reaction plays a major role in many alternative-energy systems because it provides the electrons and protons required for the use of renewable electricity. We report the tuning of the iron molybdate (FeMoO) electron structure via a coupled interface between the catalytic centers and the substrate. Our developed FeMoO catalysts can provide a 50 mA cm current density at 1.

Identifying Apoptosis-Related Transcriptomic Aberrations and Revealing Clinical Relevance as Diagnostic and Prognostic Biomarker in Hepatocellular Carcinoma.

In view of the unsatisfactory treatment outcome of liver cancer under current treatment, where the mortality rate is high and the survival rate is poor, in this study we aimed to use RNA sequencing data to explore potential molecular markers that can be more effective in predicting diagnosis and prognosis of hepatocellular carcinoma. RNA sequencing data and corresponding clinical information were obtained from multiple databases. After matching with the apoptotic genes from the Deathbase database, 14 differentially expressed human apoptosis genes were obtained.

Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways after neuronal deletion of NAMPT.

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway. Our previous study demonstrated that deletion of NAMPT gene in projection neurons using Thy1-NAMPT conditional knockout (cKO) mice causes neuronal degeneration, muscle atrophy, neuromuscular junction abnormalities, paralysis and eventually death. Here we conducted a combined metabolomic and transcriptional profiling study in an attempt to further investigate the mechanism of neuronal degeneration at metabolite and mRNA levels after NAMPT deletion.

Sediment record of heavy metals over the last 150 years in Northeast China: implications for regional anthropogenic activities.

Evidence from terrestrial sedimentary heavy metals record is a robust indicator of anthropogenic activity changes. Heavy metals and particle sizes in Pb-dated sediment cores extracted from Hulun and Chagan lakes were measured to reconstruct the sediment record and evaluated health risk of heavy metals in the last 150 years in Northeast China. In general, the particle size of Hulun Lake was finer with more contents of clay than Chagan Lake, while the concentrations of most heavy metals in Hulun Lake was lower.

The anti-inflammatory and analgesic effects of intraperitoneal melatonin after spinal nerve ligation are mediated by inhibition of the NF-κB/NLRP3 inflammasome signaling pathway.

Objective: To explore the potential analgesic effect of melatonin and its underlying molecular mechanisms in a neuropathic pain model induced by spinal nerve ligation (SNL).

Methods: The experimental animals were divided into different groups including sham, vehicle, melatonin (MT) treatment, caspase-1 inhibitor (VX-765) treatment and MT2 antagonist (4P-PDOT) treatment. On the first three successive postoperative days, rats were intraperitoneally administered with MT, VX-765 or combination of MT and 4P-PDOT.

Human ClpP protease, a promising therapy target for diseases of mitochondrial dysfunction.

Human caseinolytic protease P (HsClpP), an ATP-dependent unfolding peptidase protein in the mitochondrial matrix, controls protein quality, regulates mitochondrial metabolism, and maintains the integrity and enzyme activity of the mitochondrial respiratory chain (RC). Studies show that abnormalities in HsClpP lead to mitochondrial dysfunction and various human diseases. In this review, we provide a comprehensive overview of the structure and biological function of HsClpP, and the involvement of its dysexpression or mutation in mitochondria for a panel of important human diseases.

Embedded homogeneous ultra-fine Pd nanoparticles within MOF ultra-thin nanosheets for heterogeneous catalysis.

Metal nanoparticle-incorporated metal-organic framework (MOF) nanosheets can integrate their respective merits to have important applications in heterogeneous catalysis. Herein, we report the loading of ultra-fine Pd nanoparticles within ultra-thin nanosheets NMOF-Ni through an in situ reduction strategy under mild conditions. Owing to the synergetic effects of ultra-small Pd NPs and the intrinsic characteristics of two-dimensional supports, the obtained Pd@NMOF-Ni showed high catalytic activity and size-selectivity in olefin hydrogenation with easy recovery.

Risk factors for illness severity in patients with COVID-19 pneumonia: a prospective cohort study.

Although COVID-19 pneumonia is spreading internationally, knowledge regarding the factors associated with the illness severity of patients remains limited. We aimed to identify the factors associated with the disease severity of patients with COVID-19 pneumonia induced by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We prospectively enrolled a single-center case series of adult patients with COVID-19 admitted to the Infectious Disease Hospital of Jining, Jining City, Shandong Province, China, from January 24 to March 1, 2020.

Structural insights into a new substrate binding mode of a histidine acid phosphatase from Legionella pneumophila.

MapA is a histidine acid phosphatase (HAP) from Legionella pneumophila that catalyzes the hydroxylation of a phosphoryl group from phosphomonoesters by an active-site histidine. Several structures of HAPs, including MapA, in complex with the inhibitor tartrate have been solved and the substrate binding tunnel identified; however, the substrate recognition mechanism remains unknown. To gain insight into the mechanism of substrate recognition, the crystal structures of apo-MapA and the MapA mutant in complex with 5'-AMP were solved at 2.

Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro.

Ethnopharmacological Relevance: After cerebral ischemia/reperfusion injury, pro-inflammatory M1 and anti-inflammatory M2 phenotypes of microglia are involved in neuroinflammation, in which activation of NLRP3 inflammasome and subsequent pyroptosis play essential roles. Salvianolic Acids for Injection (SAFI) is Chinese medicine injection which composed of multiple phenolic acids extracted from Radix Salviae Miltiorrhizae, and has been reported to generate neuroprotective effects after cerebral ischemic insult in clinical and animal studies.

Aim Of The Study: The present study was designed to investigate whether SAFI exerts neuroprotective effects by switching microglial phenotype and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia.