Urolithin A attenuates hexavalent chromium-induced small intestinal injury by modulating PP2A/Hippo/YAP1 pathway.

Hexavalent chromium (Cr(VI)) exposure has been linked with gastrointestinal toxicity, whereas the molecular pathways and key targets remain elusive. Computational toxicology analysis predicted the correlation between protein phosphatase 2A (PP2A) and genes regarding Cr(VI)-induced intestinal injury. Here, we generated a mouse model with intestinal epithelium-specific knock out of Ppp2r1a (encoding PP2A Aα subunit) to investigate the mechanisms underlying Cr(VI)-induced small intestinal toxicity.

Quantitative structure-toxicity relationships of halobenzoquinone isomers on DNA reactivity and genotoxicity.

Halobenzoquinones (HBQs) are an emerging class of drinking water disinfection byproducts that have been predicted as bladder carcinogens. However, data on the genotoxicity of HBQs are still scarce. This study performed a quantitative structure-toxicity relationship (QSTR) analysis of HBQ isomers on DNA reactivity and genotoxicity.

Particle size distribution and pollutant dissolution characteristics of road-deposited sediment in different land-use districts: a case study of Beijing.

The high pollutants loading of road-deposited sediment (RDS) make it the main threat to receiving water bodies in stormwater management; however, the characteristics of RDS have not yet been sufficiently studied. In this study, samples were collected from three different land-use type areas (campus, residential, and commercial) in Beijing, China, and analyzed for particle size distribution, chemical compositions, and dissolution characteristics. The results revealed that RDS in the sampling sites mainly consisted of particles < 63 μm, which accounted for 40.