IRGM Inhibits the AKT/mTOR Signaling Pathway by Interacting with TRIM21 to Alleviate Sepsis-Induced Acute Lung Injury.

Acute lung injury (ALI) is a severe complication of sepsis, and its underlying pathological mechanisms remain poorly understood. This study aims to investigate the role and mechanisms by which IRGM mediates autophagy through the regulation of the AKT/mTOR signaling pathway in sepsis-induced ALI. Initially, a sepsis-induced ALI mouse model was established using cecal ligation and puncture (CLP).

Spatial transcriptomic characterization of a Carnegie stage 7 human embryo.

Gastrulation marks a pivotal stage in mammalian embryonic development, establishing the three germ layers and body axis through lineage diversification and morphogenetic movements. However, studying human gastrulating embryos is challenging due to limited access to early tissues. Here we show the use of spatial transcriptomics to analyse a fully intact Carnegie stage 7 human embryo at single-cell resolution, along with immunofluorescence validations in a second embryo.

Oral traditional Chinese medicine for mild to moderate cases of COVID-19: a network meta-analysis based on RCTs.

Introduction: This systemic review examines the effectiveness and safety of combining traditional Chinese medicine with standard therapy in the treatment of mild to moderate cases of coronavirus disease 2019 (COVID-19).

Methodology: We retrieved articles from PubMed, Web of Science, Cochrane, Embase, China National Knowledge Infrastructure (CNKI), Wanfang, Weipi (VIP), and China Biology Medicine disc (CBM). The deadline for retrieval was 20 August 2022, and it was updated on 1 July 2023.

IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.

Background: Sepsis is a life-threatening condition characterized by organ dysfunction due to an impaired immune response to infection. The lungs are highly susceptible to infection, often resulting in acute lung injury (ALI). The immune-related GTPase M (IRGM) and its murine homolog Irgm1 mediate autophagy and are implicated in inflammatory diseases, yet their roles in sepsis-induced ALI remain unclear.

Clinical Pharmacist Involved in the Treatment of Pneumonia: A Case Report.

Objective: The first-line treatment for severe pneumonia (PCP) is trimethoprim-sulfamethoxazole (TMP/SMZ). Here, we report a case involving 6-month-old child with a PCP infection, highlighting the role of clinical pharmacists in providing individualized pharmaceutical care and guidance through the process of therapeutic drug monitoring (TDM).

Methods: The clinical pharmacist monitored the concentration of TMP/SMZ in the serum, urine and sputum of a 6-month-old child with PCP infection.

Retraction Notice to: Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression.

[This retracts the article DOI: 10.1016/j.omtn.

3D reconstruction of a gastrulating human embryo.

Progress in understanding early human development has been impeded by the scarcity of reference datasets from natural embryos, particularly those with spatial information during crucial stages like gastrulation. We conducted high-resolution spatial transcriptomics profiling on 38,562 spots from 62 transverse sections of an intact Carnegie stage (CS) 8 human embryo. From this spatial transcriptomic dataset, we constructed a 3D model of the CS8 embryo, in which a range of cell subtypes are identified, based on gene expression patterns and positional register, along the anterior-posterior, medial-lateral, and dorsal-ventral axis in the embryo.

The causal effects of age at menarche and age at menopause on sepsis: A two-sample Mendelian randomization analysis.

Objectives: To determine whether the age at menarche (AAM) and the age at menopause (ANM) are causally related to the development of sepsis.

Methods: We performed a two-sample Mendelian randomization (MR) analysis by utilizing summary statistics from genome-wide association study (GWAS) datasets for both the exposure and outcome variables. Single nucleotide polymorphisms (SNPs) that exhibited significant associations with AAM and ANM were chosen as instrumental variables to estimate the causal effects on sepsis.

Decolorization of Textile Azo Dye via Solid-State Fermented Wheat Bran by sp. YZH1.

Textile dyes are one of the major water pollutants released into water in various ways, posing serious hazards for both aquatic organisms and human beings. Bioremediation is a significantly promising technique for dye decolorization. In the present study, the fungal strain sp.

Interface regulation of Zr-MOF/NiP@nickel foam as high-efficient electrocatalyst for pH-universal hydrogen evolution reaction.

Currently, the development of economical and effective non-noble metal electrocatalysts is vital for advancing hydrogen evolution reaction (HER) and enabling its widespread applications. The customizable pore structure and enormous surface area of metal-organic frameworks (MOFs) have made them to become promising non-noble metal electrocatalysts for HER. However, MOFs have some challenges, including low conductivity and instability, which can result in them having high overpotentials and slow reaction kinetics in electrocatalytic processes.

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxic respiratory failure: a systematic review based on eight high-quality randomized controlled trials.

Background: Awake prone positioning has been widely used in non-intubated patients with acute hypoxic respiratory failure (AHRF) due to COVID-19, but the evidence is mostly from observational studies and low-quality randomized controlled trials (RCTs), with conflicting results from published studies. A systematic review of published high-quality RCTs to resolve the controversy over the efficacy and safety of awake prone positioning in non-intubated patients with AHRF due to COVID-19.

Methods: Candidate studies were identified through searches of PubMed, Web of Science, Cochrane, Embase, Scopus databases from December 1, 2019 to November 1, 2022.

Survival outcomes of robotic-assisted laparoscopy versus conventional laparoscopy and laparotomy for endometrial cancer: A systematic review and meta-analysis.

Objective: Robotic-assisted laparoscopy (RALS) has gained widespread acceptance in the field of gynecological oncology. However, whether the prognosis of endometrial cancer after RALS is superior to conventional laparoscopy (CLS) and laparotomy (LT) remains inconclusive. Therefore, the aim of this meta-analysis was to compare the long-term survival outcomes of RALS with CLS and LT for endometrial cancer.

Extended application of defective metal oxide BiO: Liquid phase low-temperature thermal catalysis for the removal of phenolic pollutants.

Bismuth oxide (BiO) with oxygen vacancies was created using a hydrothermal process and was found to exhibit good catalytic oxidation performance under low-temperature heating without the addition of external oxidants. The catalytic activity of BiO was tested using 4-chlorophenol (4-CP) as the target aqueous pollutant. We observed that 10 ppm of 4-CP was completely degraded within 40 min at a reaction temperature of 65 °C.

Zr-MOF/NiS hybrids on nickel foam as advanced electrocatalysts for efficient hydrogen evolution.

As a typical transition-metal sulfides (TMS), nickel disulfide (NiS) has attracted great attention in terms of hydrogen evolution reaction (HER). Howbeit, owing to the poor conductivity, slow reaction kinetics and instability of NiS, its HER activity is still necessary to be improved. In this work, we designed hybrid structures consisting of the nickel foam (NF) as a self-supporting electrode, NiS derived from the sulfuration of NF and Zr-MOF grown on the surface of NiS@NF (Zr-MOF/NiS@NF).

Carbon emission effects of publicly planned logistics nodes: experience from Chengdu, China.

Both academics and policymakers regard publicly planned logistics nodes (PPLN) as a potential measure to promote logistics agglomeration and mitigate environmental damage caused by logistics activities. However, such measure may lead to non-linear carbon emission effect from the perspective of agglomeration economy, and empirical evidences are yet to be found to verify this inference. This paper uses DID method and mediating effect models to explore the effects and mechanisms of PPLN on CO emissions with panel data from 2000 to 2017 in Chengdu, China.

Bifunctional 2D/2D g-CN/BiO nanosheets heterojunction for bacterial disinfection mechanisms under visible and near-infrared light irradiation.

The efficient deployment of visible and near-infrared (NIR) light for photocatalytic disinfection is of great concern a matter. Herein, we report a specific bifunctional 2D/2D g-CN/BiO nanosheets heterojunction, prepared through a self-assembly approach. Delightfully, the obtained 2D/2D heterojunctions exhibited satisfactory photocatalytic disinfection performance towards Escherichia coli K-12 (E.

Identification of Immune-Related Key Genes as Potential Diagnostic Biomarkers of Sepsis in Children.

Objective: The pathogenesis of sepsis is still unclear due to its complexity, especially in children. This study aimed to analyse the immune microenvironment and regulatory networks related to sepsis in children at the molecular level and to identify key immune-related genes to provide a new basis for the early diagnosis of sepsis.

Methods: The GSE145227 and GSE26440 datasets were downloaded from the Gene Expression Omnibus.

Prussian blue analogue derived cobalt-nickel phosphide/carbon nanotube composite as electrocatalyst for efficient and stable hydrogen evolution reaction in wide-pH environment.

Transition metal phosphides, especially bimetallic phosphides, are promising noble-metal-free electrocatalysts for hydrogen evolution reaction (HER). However, their inferior charge transfer ability constrains further performance improvement. In this work, a facile strategy is reported to fabricate CoP/NiP/carbon nanotube (CNT) composite from a precursor Co-Ni Prussian blue analogue.

Enhanced hydrogen evolution reaction in alkaline solution by constructing strong metal-support interaction on Pd-CeO-NC hybrids.

Diminishing the size of metal nanostructures can significantly improve the performance of catalysts. However, the self-aggregation of small particles is still an insurmountable obstacle, resulting in the unfavorable stability and recyclability. Herein, we designed and fabricated the Pd-CeO-NC catalyst though an accurate deposition strategy to downsize the Pd particle to sub-nanometer level and enhance its running stability.

A system dynamics model to simulate the water-energy-food nexus of resource-based regions: A case study in Daqing City, China.

Resource-based regions (RBRs) have made significant contributions to the social and economic development of nations. The long-term and high-intensity development of resources puts tremendous pressure on water, energy and food resources and the ecological environment. Exploring the water-energy-food nexus (WEF nexus, WEFN) of RBRs is key to making informed decisions about regional sustainable development.

Well-designed oxidized Sb/g-CN 2D/2D nanosheets heterojunction with enhanced visible-light photocatalytic disinfection activity.

2D/2D heterojunction photocatalysts with excellent photocatalytic activity highlight considerable potential in water disinfection. Here, an oxidized Sb/g-CN 2D/2D nanosheets heterojunction (Sb-SbO/CNS) was constructed based on a facile one-step liquid-phase exfoliation method using concentrated sulfuric acid. By doing so, bulk Sb and g-CN were exfoliated simultaneously and then, intercalated each other.

The impact of marital status on stage at diagnosis and survival of female patients with breast and gynecologic cancers: A meta-analysis.

The aim of this meta-analysis is to evaluate the effect of marital status on the stage at diagnosis and survival of female patients with breast and gynecologic cancers. A systematic literature search was conducted on electronic databases (PubMed, Cochrane and EMBASE) till December 31, 2020. Publications investigating the association of marital status with stage at diagnosis and/or cancer-specific mortality (CSM) and/or overall survival (OS) in female patients with breast or gynecologic cancers were retrieved.

Risk factors for mortality of critically ill patients with COVID-19 receiving invasive ventilation.

Early invasive ventilation may improve outcomes for critically ill patients with COVID-19. The objective of this study is to explore risk factors for 28-day mortality of COVID-19 patients receiving invasive ventilation. 74 consecutive adult invasively ventilated COVID-19 patients were included in this retrospective study.

miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer.

Cervical cancer is one of the most prevalent malignancies in women worldwide. Therefore, investigation about molecular pathogenesis and related therapy targets of cervical cancer is an emergency. The molecular mechanisms responsible for the chemoresistance of cervical cancer were investigated by the use of doxorubicin (Dox)-resistant HeLa/Dox and SiHa/Dox cells.