Publications by authors named "Nanfang Mo"
Background: Anti-interferon-γ autoantibodies (AIGAs) are associated with adult-onset immunodeficiency syndrome, which makes individuals susceptible to intracellular pathogen infections. However, AIGAs are rarely reported in adolescents.
Case Presentation: We report a 13-year-old Chinese boy who presented with fever, cough, and enlarged cervical lymph nodes.
Background: Voriconazole (VRC) has been used as an alternative treatment for talaromycosis. However, there are few studies reporting the VRC plasma concentration in patients with talaromycosis. The purpose of this study was to analyze the correlations between VRC initial steady-state trough concentration and clinical outcomes.
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- Increasing reports of phaeohyphomycosis in both animals and humans raise concerns as the pathogenesis and virulence of the implicated fungus remain underexplored.
- Experimental studies on BALB/c mice showed that different inoculation routes led to skin lesions and confirmed infection through mycological and histopathological methods.
- Voriconazole was found to be the most effective antifungal treatment against the fungus, while fluconazole showed the least effectiveness, indicating a need for further research into its pathogenicity.
Article Synopsis
- Researchers developed a new method using an asymmetric organocatalyzed three-component Povarov reaction to create azaspirocycles.
- A specialized chiral phosphoric acid with a -CF-aryl group was highly effective in this reaction.
- The process achieved high yields and excellent enantioselectivities, broadening the types of substrates that can be used compared to traditional Povarov reactions.
Aberrant DNA replication is one of the driving forces behind oncogenesis. Furthermore, minichromosome maintenance complex component 3 (MCM3) serves an essential role in DNA replication. Therefore, in the present study, the diagnostic and prognostic value of MCM3 and its interacting proteins in hepatocellular carcinoma (HCC) were investigated.
View Article and Find Full Text PDFBackground: Cystic fibrosis transmembrane conductance regulator IVS8-5T gene variation appears to be associated with a higher risk of chronic pancreatitis (CP); however, there is inconsistency between previous reported studies. Here, we performed a meta-analysis to investigate this relationship.
Materials And Methods: PubMed and WANFANG databases were searched for the case-control studies that contained Patients with CP with IVS8-5T variation.
Background: Radiation sensitive 52 (RAD52) is an important protein that mediates DNA repair in tumors. However, little is known about the impact of RAD52 on hepatocellular carcinoma (HCC). We investigated the expression of RAD52 and its values in HCC.
View Article and Find Full Text PDFHuman leukocyteantigen (HLA) is the most important gene for immune system regulation. Although studies have evaluated the association between HLA-DRB1 allele polymorphisms and systemic sclerosis (SSc), their results are still controversial. We performed a meta-analysis to assess the association of HLA-DRB1 alleles with risk of SSc.
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