Publications by authors named "Nanfang Li"
Introduction: To develop a validated risk prediction model for placental abruption in preeclamptic patients with singleton pregnancies firstly.
Methods: Data from 1448 preeclamptic patients with singleton pregnancies who delivered between January 2013 and December 2022 were reviewed. Variables, including demographic characteristics, laboratory test results, comorbidities, and aspirin use were collected and analyzed.
Cross-sectional association between plasma aldosterone concentration and cognitive performance by mini-mental state examination in community dwellers.
Front Nutr
February 2025
Background: Aldosterone is the effector hormone in the renin angiotensin aldosterone system and existing data suggest aldosterone affect cognitive function. However, the relationship between plasma aldosterone concentration (PAC) and cognitive performance remains unexplored in community dwellers. Therefore, we aimed to explore whether PAC is associated with cognitive performance in this population.
View Article and Find Full Text PDFObjectives: Polyarteritis nodosa (PAN) is a rare autoimmune disease that can cause severe functional impairment. Early diagnosis and timely intervention are essential to reduce disease severity and improve outcomes.
Methods: Serum proteins from PAN patients and healthy controls were analyzed using data-independent acquisition mass spectrometry (DIA-MS), identifying 55 differentially expressed proteins.
Objective: Hypertension development and progression are largely influenced by inflammation, which plays a critical role by activating the immune system and causing damage to the vascular endothelium. Metabolic dysfunction-associated fatty liver disease (MAFLD) is also associated with chronic low-grade inflammation, which drives disease progression via metabolic imbalances and adipose tissue dysfunction. This study investigates the relationship between inflammatory indices and MAFLD in hypertensive patients and assesses the predictive accuracy of these indices for MAFLD.
View Article and Find Full Text PDFPurpose: Limited studies have examined the relationship between plasma aldosterone concentration (PAC) and arterial stiffness progression. This study aimed to investigate the longitudinal association between baseline PAC and arterial stiffness progression in hypertensive patients.
Patients And Methods: This was a longitudinal study conducted at the Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region between April 2020 and October 2023.
Background: The influence of serum uric acid (SUA) on bone metabolism, as suggested by previous studies, remains a contentious issue. SUA plays a complex role in bone health and hypertension, making it challenging to discern its impact on the skeletal status of middle-aged and elderly hypertensive patients. This study aims to elucidate the effects of SUA on bone health, with a particular focus on its association with osteoporosis and the risk of fractures.
View Article and Find Full Text PDFOutcomes after medical treatment for primary aldosteronism: an international consensus and analysis of treatment response in an international cohort.
Lancet Diabetes Endocrinol
February 2025
Background: Primary aldosteronism can be treated medically but there is no standardised method to evaluate treatment outcomes. We aimed to develop criteria for assessing the outcomes of targeted medical treatment of primary aldosteronism, analyse outcomes across an international cohort, and identify factors associated with a complete treatment response.
Methods: An international panel of 31 primary aldosteronism experts used the Delphi method to reach consensus on the definition of complete, partial, or absent biochemical and clinical outcomes of medical treatment of primary aldosteronism.
The Cross-Sectional Association Between Multimorbidity and Sleep Quality and Duration Among the Elderly Community Dwellers in Northwest China.
Nat Sci Sleep
December 2024
Background: Multimorbidity, defined as the coexistence of two or more chronic diseases, is highly prevalent among the elderly population and is associated with adverse outcomes. However, little is known about its relationship with sleep issues, particularly in this demographic. Therefore, this study aimed to investigate its association with sleep quality and duration among the elderly.
View Article and Find Full Text PDFObjective: Admission hyperglycaemia is recognized as a contributor to poor outcomes in patients with cardiovascular and cerebrovascular diseases. This study aimed to evaluate the association between admission hyperglycaemia and in-hospital mortality in patients with hypertension and acute aortic dissection (AAD).
Methods: Patients diagnosed with hypertension and AAD between 1 January 2010 and 1 March 2023 were enrolled into this retrospective observational study, and divided into two groups based on admission blood glucose levels (BGA): normoglycemia (BGA < 7.
Chinese expert consensus on the management of hypertension in adults with type 2 diabetes.
J Evid Based Med
December 2024
Article Synopsis
- Hypertension and type 2 diabetes contribute to an increased risk of premature death and related diseases, particularly affecting the same population.
- An expert consensus using the GRADE approach was formed to create strategies aimed at reducing cardiovascular and kidney-related deaths while minimizing treatment burdens for adults with type 2 diabetes.
- A multidisciplinary team developed 12 evidence-based recommendations focusing on screening, monitoring, lifestyle changes, and medication for individuals with type 2 diabetes, specifically addressing those who also have hypertension.
The objective of this study was to ascertain the relationship between the weight-adjusted waist index (WWI) and the risk of stroke in an elderly hypertensive population, a relationship that has not been previously elucidated. The Cox regression model was employed to assess the correlation between baseline WWI measurements and the incidence of stroke. To further elucidate the shape of the association between baseline WWI and stroke, restricted cubic splines were employed.
View Article and Find Full Text PDFCorrection: Associated lifestyle factors of elevated plasma aldosterone concentration in community population, gender-stratified analysis of a cross-sectional survey.
BMC Public Health
October 2024
Objective: To explore the link between plasma aldosterone concentration (PAC) and the prevalence of metabolic dysfunction-related fatty liver disease (MAFLD) in hypertensive patients.
Methods: We analyzed data from 41,131 hospitalized patients from January 1, 2014, to December 31, 2023. Multivariate logistic regression models tested associations, with threshold, subgroup, and sensitivity analyses conducted to validate findings.
Background: Obesity is linked to a variety of psychosocial and behavioral outcomes but the causalities remain unclear yet. Determining the causalities and distinguishing between the separate effects of childhood and adult obesity is critical to develop more targeted strategies to prevent adverse outcomes.
Methods: With single nucleotide polymorphisms (SNPs) used as genetic variables, we employed univariable Mendelian randomization (UVMR) to explore the causalities between childhood and adult body mass index (BMI) and socioeconomic status, psychological status, and substance use.
Article Synopsis
- The study investigates the relationship between obstructive sleep apnea (OSA) and proteinuria in patients with hypertension, suggesting that OSA may be an independent risk factor for kidney damage.
- It involved a cross-sectional analysis of 2,106 participants, where those with more severe OSA were found to have a progressively higher risk of proteinuria compared to those without OSA.
- Key findings include that higher apnea hypopnea index (AHI) and time spent with low oxygen saturation correlate with increased likelihood of proteinuria, indicating that OSA severity is linked to renal impairment in hypertensive patients.
Objective: Previous studies focusing on primary aldosteronism (PA) and thyroid diseases were controversial. Hence, this study aimed to examine associations between thyroid function, thyroid diseases, and PA and its subtypes.
Design And Methods: This was a cross-sectional study, which enrolled 1023 patients with PA and 6138 patients with essential hypertension (EH) admitted to Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region from August 2011 to June 2022.
Article Synopsis
- Sleep is super important for staying healthy, and when we don't get enough of it, our bodies don't work right, which can cause problems with thinking and heart health.
- Scientists experimented on mice with sleep troubles and found they had problems with thinking and processing sugar.
- By increasing a substance called acetate in the mice, the researchers were able to help improve their thinking and metabolism, showing that acetate might protect us from the bad effects of not sleeping well.
Plasma aldosterone concentrations elevation in hypertensive patients: the dual impact on hyperuricemia and gout.
Front Endocrinol (Lausanne)
August 2024
Background: Prior research has highlighted the association between uric acid (UA) and the activation of the renin-angiotensin-aldosterone system (RAAS). However, the specific relationship between aldosterone, the RAAS's end product, and UA-related diseases remains poorly understood. This study aims to clarify the impact of aldosterone on the development and progression of hyperuricemia and gout in hypertensive patients.
View Article and Find Full Text PDFObjective: To investigate the potential affective factors of depressive symptoms in patients with hypertension and explore the protective effects of physical activity.
Methods: 211 hypertensive patients aged over 18 years were consecutively recruited. All patients completed a self-designed questionnaire and the Hospital Anxiety and Depression Scale (HADS) to assess the coexistence of depressive symptoms, and psychiatrists were invited to diagnose depression when necessary.
Article Synopsis
- - The study investigates the relationship between the hepatic steatosis index (HSI) and cardiovascular disease risk in hypertensive patients with obstructive sleep apnea, noting that these patients often face limitations due to other health conditions.
- - Utilizing a cohort of 2467 patients, the research categorizes individuals based on their HSI and finds that those in the highest quartile (Q4) experience significantly worse survival outcomes and higher rates of major cardiovascular events.
- - Results indicate a clear linear relationship where an increase in HSI correlates with a higher risk of new or recurring cardiovascular events, suggesting that tracking HSI could help in predicting CVD risks in this patient group.
Article Synopsis
- A new big data intelligence platform called Hypertension DATAbase at Urumchi (UHDATA) was created to enhance the identification and research of secondary hypertension using electronic medical records from a hospital in Xinjiang, China.
- The platform has accumulated data from 295,297 hypertensive patients since 2004, including demographic and medical information, with a focus on diagnosing secondary hypertension, which affected 14% of the total.
- The database can be updated with new patient information and follow-ups every two weeks, enabling continuous research and has already facilitated multiple published studies.
There are no nationwide surveys on antihypertensive drugs in China. In order to assess the current status of antihypertensive drug therapy in patients with hypertension and analyzed factors that may affect combination therapy, using convenience sampling, we recruited 305,624 patients with hypertension from the Chinese Cardiovascular Association Database-Hypertension Center between January 2019 and December 2021. Chi-squared test was performed to analyze the administered antihypertensive drug types and their combinations in different hospital settings.
View Article and Find Full Text PDFBackground: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD). Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort.
Methods: A total of 2265 participants with hypertension and OSA were included in the study.
Article Synopsis
- The study investigates the impact of spironolactone, an aldosterone antagonist, on bone health, specifically focusing on osteoporosis and fracture risk in middle-aged and elderly hypertensive patients.
- Using propensity score matching and various regression analyses, the research found that spironolactone users had a significantly lower risk of developing osteoporosis compared to non-users, as evidenced by odds ratios indicating a reduced risk.
- The findings suggest that spironolactone could have a beneficial effect on bone health, leading to recommendations for larger, more comprehensive studies to assess its long-term effects in hypertensive patients.