Publications by authors named "Nandu K Thudi"
Article Synopsis
- HTLV-1 causes adult T-cell leukemia, leading to bone-related issues like hypercalcemia and osteolysis, with currently no effective treatment available.
- Research utilized mice expressing the HTLV-1 oncogene Tax to study the development and characteristics of osteolytic tumors through various scientific methods.
- The study identified Tax mouse tumors as aggressive bone-invasive histiocytic sarcomas, highlighting gene expression differences that link to tumor growth and associated inflammation, paving the way for further research on HTLV-1's impact.
Background: Parathyroid hormone-related protein (PTHrP) has anabolic effects in bone, which has led to the clinical use of N-terminal fragments of PTHrP and PTH. Since 10% to 20% of fractures demonstrate healing complications and osteoporosis continues to be a debilitating disease, the development of bone-forming agents is of utmost importance. Due to evidence that regions of PTHrP other than the N-terminus may have bone-forming effects, this study was designed to compare the effects of full-length PTHrP 1-141 to N-terminal PTHrP 1-86 on in vitro bone formation.
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