Symmetrical Bis-Hydrazone Ligand-Based Binuclear Oxido/Dioxido-Vanadium(IV/V) Complexes: Synthesis, Reactivity, and Catalytic Applications for the Synthesis of Biologically Potent 2-Phenylquinazolin-4-(3)-ones.

Symmetrical bis(hydrazone)-based ligands, Hdar(bhz) (), Hdar(fah) (), Hdar(nah) (), and Hdar(inh) () obtained from 4,6-diacetylresorcinol (Hdar) and different hydrazides [benzoylhydrazide (Hbhz), isonicotinoylhydrazide (Hinh), nicotinoylhydrazide (Hnah), and 2-furoylhydrazide (Hfah)], were used to prepare potassium salts of binuclear -[VO] complexes, {K(HO)}[(VO)dar(bhz)] (), {K(HO)}[(VO)dar(fah)] (), {K(HO)}[(VO)dar(nah)] (), and {K(HO)}[(VO)dar(inh)] (), and binuclear [VO] complexes, [{VO(MeOH)}dar(bhz)] (), [{VO(MeOH)}dar(fah)] (), [{VO(MeOH)}dar(nah)] (), and [{VO(MeOH)}dar(inh)] (). In the presence of warm MeOH/DMSO (4:1), changed to {K(HO)}[(VO)Hdar(nah)]DMSO (·DMSO). Single crystal XRD studies of and confirm a binuclear structure along with a distorted square pyramidal geometry of each vanadium center where bis{ONO(2-)} ligands coordinate through phenolate-O, azomethine-N, and enolate-O atoms of each unit.

Role of serum procalcitonin in differentiating disease flare and systemic bacterial infection among febrile children with known chronic rheumatic diseases: a cross-sectional study.

Objectives: To evaluate the role of serum procalcitonin (PCT) as a diagnostic tool to differentiate bacterial sepsis from flare-ups during febrile episodes in children with known rheumatic disorders compared to other inflammatory markers like C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).

Methods: Previously diagnosed patients with known rheumatic disorders presenting in emergency or outpatient departments with febrile episodes were included in the study. Blood samples were collected upon admission to test for signs of infection, including serum PCT levels with routine laboratory and radiological tests.

Enhancing Anemia Detection With Non-invasive Anemia Detection With AI (NiADA): Insights From Clinical Validations and Physician Observations.

Background Anemia, a critical public health issue, affects nearly two billion people globally. Frequent monitoring of blood hemoglobin levels is essential for managing its burden. While point-of-care testing (POCT) devices facilitate hemoglobin testing in resource-limited settings, most are invasive and have inherent limitations.

A generalized theoretical framework to investigate multicomponent actin dynamics.

The length of actin filaments is regulated by the combined action of hundreds of actin-binding proteins. While the roles of individual proteins are well understood, how they combine to regulate actin dynamics in vivo remains unclear. Recent advances in microscopy have enabled precise, high-throughput measurements of filament lengths over time.

Emergence of temporal noise hierarchy in co-regulated genes of multi-output feed-forward loop.

Natural variations in gene expression, called noise, are fundamental to biological systems. The expression noise can be beneficial or detrimental to cellular functions. While the impact of noise on individual genes is well-established, our understanding of how noise behaves when multiple genes are co-expressed by shared regulatory elements within transcription networks remains elusive.

Recent advances in the syntheses and emerging applications of 2D borophene-based nanomaterials with a focus on supercapacitors.

Two-dimensional (2D) nanosheets of boron, borophene, have triggered interest in progressive research as a result of the vast field of opportunities to explore, from its innovative synthetic techniques to novel properties and potential applications. It possesses exceptional tuneable properties such as mechanical flexibility, electronic and thermal conductivity, optical transparency, metallicity, anisotropy and polymorphism. This has sparked significant curiosity in the application of borophene-based materials in energy storage systems such as supercapacitors, which display high-power density with reliable energy density, fast charge/discharge kinetics and long cycle life.

Bursting gamma oscillations in neural mass models.

Gamma oscillations (30-120 Hz) in the brain are not periodic cycles, but they typically appear in short-time windows, often called oscillatory bursts. While the origin of this bursting phenomenon is still unclear, some recent studies hypothesize its origin in the external or endogenous noise of neural networks. We demonstrate that an exact neural mass model of excitatory and inhibitory quadratic-integrate and fire-spiking neurons theoretically predicts the emergence of a different regime of intrinsic bursting gamma (IBG) oscillations without any noise source, a phenomenon due to collective chaos.

Channel assisted noise propagation in a two-step cascade.

Signal propagation in biochemical networks is characterized by the inherent randomness in gene expression and fluctuations of the environmental components, commonly known as intrinsic and extrinsic noise, respectively. We present a theoretical framework for noise propagation in a generic two-step cascade (S→X→Y) regarding intrinsic and extrinsic noise. We identify different channels of noise transmission that regulate the individual and the overall noise properties of each component.

Unified Language for Knowledge Dissemination: The Vascular Ageing Glossary, an Initiative by VascAgeNet.

Objectives: In general, a terminology shared and agreed by different stakeholders is important to facilitate communication and cooperation. This holds true in the field of vascular ageing for the benefit of global cardiovascular health. The need to promote a common language and understanding across this area was recognised by VascAgeNet, a collaborative network with relevant and diverse expertise in the vascular ageing field, supported by the European Cooperation in Science and Technology.

Ni-Unsymmetrical Salen Complex-Catalyzed One-Pot Multicomponent Reactions for Efficient Synthesis of Biologically Active 2-Amino-3-cyano-4-pyrans.

In this report, four new Ni(II)-unsymmetrical salen complexes, [NiL], were prepared by refluxing Ni(Ac)·4HO with unsymmetrical salen ligands, HL. All of the synthesized ligands and complexes were characterized by various physicochemical methods. Also, the solid-state structures of [NiL], [NiL], and [NiL] were defined through single-crystal X-ray diffraction methods.

Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction.

The potential for unintended drug induced changes in cardiac contractility is a major concern in medicines development. Whilst direct left ventricular pressure (LVP) measurement is the gold standard for measuring cardiac contractility in vivo, it is resource intensive and poses a welfare burden on research animals. In contrast, arterial blood pressure (BP) measurement has fewer challenges.

Motility driven glassy dynamics in confluent epithelial monolayers.

As wounds heal, embryos develop, cancer spreads, or asthma progresses, the cellular monolayer undergoes a glass transition between solid-like jammed and fluid-like flowing states. During some of these processes, the cells undergo an epithelial-to-mesenchymal transition (EMT): they acquire in-plane polarity and become motile. Thus, how motility drives the glassy dynamics in epithelial systems is critical for the EMT process.

The Spectrum of Intracranial Arteriopathies and Ischemic Strokes in Pediatric Tubercular Meningitis: A Tricentric Study From Eastern India.

Introduction: Addressing the need to uniformly classify arteriopathies among patients with arterial ischemic stroke (AIS) due to tubercular meningitis (TBM), we used the Childhood AIS Standardised Classification and Diagnostic Evaluation (CASCADE) criteria.

Methods: This tri-centric prospective study included children aged 0.5-12 years with TBM and AIS.

Thermal and protonation-induced electron transfer coupled spin transition in a discrete [FeCo] Prussian blue analogue.

Multi-stimuli responsive switchable molecules have garnered interest for their potential applications in the field of magnetic materials. However, the persistent challenge lies in isolating these properties within the same material. Herein, we report a discrete [FeCo] pentanuclear cyanide bridged complex, [Co(L)][Fe(CN)]·20HO, (1) (L = ()-'-(4-(trifluoromethyl)phenyl)picolinimidamide) which undergoes electron transfer coupled spin transition (ETCST) from [FeII2CoIIHSCoIII2] to [FeIII2CoII3] configurations through thermal activation and upon protonation.

Ni Single Atom Decorated Porous Hollow Carbon Nanosphere-Based Electrodes for High Performance Symmetric Solid-State Supercapacitors.

Ni single atom containing hollow carbon nanospheres with nitrogen doping has been synthesized by carbonization of Ni(NO)/phloroglucinol-formaldehyde polymer/silica composite. The samples have been characterized by powder X-ray diffraction, nitrogen adsorption/desorption, electron microscopic, Raman and X-ray photoelectron spectroscopic studies. The microstructure and surface area vary with the amount of Ni(NO) employed in the syntheses and the carbonization environment.

Toward Circular Recycling of Polyurethanes: Depolymerization and Recovery of Isocyanates.

We report a depolymerization strategy to nearly quantitatively regenerate isocyanates from thermoplastic and thermoset polyurethanes (PUs) and then resynthesize PUs using the recovered isocyanates. To date, chemical/advanced recycling of PUs has focused primarily on the recovery of polyols and diamines under comparatively harsh conditions ( high pressure and temperature), and the recovery of isocyanates has been difficult. Our approach leverages an organoboron Lewis acid to depolymerize PUs directly to isocyanates under mild conditions ( ∼80 °C in toluene) without the need for phosgene or other harsh reagents, and we show that both laboratory-synthesized and commercially sourced PUs can be depolymerized.

Polymer Supported Nitrogen-Bridged Symmetrical Binuclear Dioxidomolybdenum(VI) Complexes and Their Homogeneous Analogues as Potential Catalysts for Efficient Synthesis of 2-Amino-3-Cyano-4H-Chromenes/Pyrans.

Reaction of 2-chloromethyl-1H-benzimidazole with known intermediates (i-iii), prepared from diaminoguanidine hydrochloride with salicylaldehyde, 5-bromosalicylaldehyde or 3,5-di-tert-butylsalicylaldehyde, in the presence of triethylamine (NEt) led to the formation of benzimidazole appended new ligands, HL-HL (I-III). The homogeneous nitrogen-bridged symmetrical binuclear complexes, [(MoO)(L)(HO)] (1), [(MoO)(L)(HO)] (2) and [(MoO)(L)(MeOH)] (3) have been isolated by reacting these ligands with [MoO(acac)] in a 1 : 2 molar ratio in refluxing methanol. Using 1 : 1 (ligand to Mo precursor) molar ratio under above reaction conditions resulted in the corresponding mononuclear complexes, [MoO(HL)(MeOH)] (4), [MoO(HL)(HO)] (5) and [MoO(HL)(MeOH)] (6).

A deeper insight into the evaluation of water-in-oil amicroemulsion templated samarium sulfide nanospheres: exploring its role in pickering emulsion formulation for photocatalytic dye degradation and synthesis of PANI@SmS nanocomposites.

This study examines the effectiveness of W/O microemulsion-mediated SmS nanospheres in pickering emulsion-based crystal violet (CV) dye degradation and PANI@SmS nanocomposite synthesis. The evaluation of nanospheres inside the core of reverse micelles was performed through DLS, TEM and FESEM analyses. The formation of nanospheres involve two phases: a nucleation phase (5-30 min) and growth phase (30-120 min).

Advanced waveform analysis of the photoplethysmogram signal using complementary signal processing techniques for the extraction of biomarkers of cardiovascular function.

Introduction: Photoplethysmogram signals from wearable devices typically measure heart rate and blood oxygen saturation, but contain a wealth of additional information about the cardiovascular system. In this study, we compared two signal-processing techniques: fiducial point analysis and Symmetric Projection Attractor Reconstruction, on their ability to extract new cardiovascular information from a photoplethysmogram signal. The aim was to identify fiducial point analysis and Symmetric Projection Attractor Reconstruction indices that could classify photoplethysmogram signals, according to age, sex and physical activity.

Catalytic, Antifungal, and Antiproliferative Activity Studies of a New Family of Mononuclear [VO]/[VO] Complexes.

Ligands derived from 2-(1-phenylhydrazinyl)pyridine and salicylaldehyde (HL), 3-methoxysalicylaldehyde (HL), 5-bromosalicylaldehyde (HL), and 3,5-di--butylsalicylaldehyde (HL) react with [VO(acac)] in MeOH followed by aerial oxidation to give [VO(L)] (), [VO(L)] (), [VO(L)] (), and [VO(L)] (). Complex [VO(acac)(L)] () is also isolable from [VO(acac)] and HL in dry MeOH. Structures of all complexes were confirmed by single-crystal X-ray and spectroscopic studies.

From construction to application of a new generation of interlocked molecules composed of heteroditopic wheels.

Over the last few decades, research on mechanically interlocked molecules has significantly evolved owing to their unique structural features and interesting properties. A substantial percentage of the reported works have focused on the synthetic strategies, leading to the preparation of functional MIMs for their applications in the chemical, materials, and biomedical sciences. Importantly, various macrocyclic wheels with specific heteroditopicity (including phenanthroline, amide, amine, oxy-ether, isophthalamide, calixarene and triazole) and threading axles (bipyridine, phenanthroline, pyridinium, triazolium, ) have been designed to synthesize targeted multifunctional mononuclear/multinuclear pseudorotaxanes, rotaxanes and catenanes.

SARS-CoV-2 spike antigen-specific B cell and antibody responses in pre-vaccination period COVID-19 convalescent males and females with or without post-covid condition.

Background: Following SARS-CoV-2 infection a significant proportion of convalescent individuals develop the post-COVID condition (PCC) that is characterized by wide spectrum of symptoms encompassing various organs. Even though the underlying pathophysiology of PCC is not known, detection of viral transcripts and antigens in tissues other than lungs raise the possibility that PCC may be a consequence of aberrant immune response to the viral antigens. To test this hypothesis, we evaluated B cell and antibody responses to the SARS-CoV-2 antigens in PCC patients who experienced mild COVID-19 disease during the pre-vaccination period of COVID-19 pandemic.

Noninvasive hemodynamic indices of vascular aging: an in silico assessment.

Vascular aging (VA) involves structural and functional changes in blood vessels that contribute to cardiovascular disease. Several noninvasive pulse wave (PW) indices have been proposed to assess the arterial stiffness component of VA in the clinic and daily life. This study investigated 19 of these indices, identified in recent review articles on VA, by using a database comprising 3,837 virtual healthy subjects aged 25-75 yr, each with unique PW signals simulated under various levels of artificial noise to mimic real measurement errors.