Publications by authors named "Nandha Joyson"
One Platform Comparison of Polymeric and Lipidic Nanoparticles for the Delivery of Amphotericin B.
AAPS PharmSciTech
November 2023
Article Synopsis
- - Amphotericin B (AmB) is an antibiotic used to treat fungal and protozoal infections, but its toxic oligomeric forms pose health risks; the research aimed to enhance the less toxic form of AmB using two different nanoformulations: solid lipid nanoparticles (SLNs) and zein-based nanoparticles (PNPs).
- - The study found that the particle sizes were 378.90 nm for SLNs and 184.90 nm for PNPs, with SLNs showing a higher degree of monomerization of AmB compared to PNPs, which improved the overall safety profile of the drug.
- - In vitro tests indicated better controlled release of AmB from PNPs compared to SLNs,