Publications by authors named "Nandan Padmanabha"

Chimeric antigen receptor T-cell (CAR-T) therapy is a recent advancement in precision medicine with promising results for patients with relapsed or refractory B-cell malignancies. However, rare post-therapy morphologic, immunophenotypic, and genomic alterations can occur. This study is to present a case of a patient with diffuse large B-cell lymphoma (DLBCL) who underwent anti-CD19 CAR-T therapy with disease in the uterus that showed transdifferentiation to a poorly differentiated malignant neoplasm that failed to express any lineage specific markers.

View Article and Find Full Text PDF
Article Synopsis
  • Some doctors use a special stain called elastin to check for something called venous invasion (VI) in patients with colorectal cancer, as it can change how they treat the disease.
  • The study divided patients into two groups: one got one elastin stain, and the other got multiple stains. It found that using multiple stains helped find VI more often, especially in advanced stages of cancer.
  • However, using more than two stains didn’t really make a difference in predicting how well patients would do, so the researchers suggest sticking to using two stains for better results without going overboard.
View Article and Find Full Text PDF

Background & Objective: Cervical cancer is the most common cancer in women worldwide with high mortality, necessitating quicker diagnostic methods. We wish to enhance the existing cervical biopsies of Squamous Intraepithelial Lesions (SIL) using p16 and Ki67 as surrogate markers to assess correlation between its positivity and histological grade of the lesion.

Methods: Analysis of p16 and Ki67 expression was done on 31 histopathologically diagnosed cases of SILs.

View Article and Find Full Text PDF

Background: The highly prevalent cervical cancer can be prevented through a vaccine. However, the uptake of the Human Papillomavirus vaccine in the general population continues to be low. Medical students, as healthcare providers in the future, would be influential in affecting the community's views and thereby the uptake of the Human Papillomavirus vaccine.

View Article and Find Full Text PDF

Purpose: Obesity in females is an emerging health problem. The consumption of MSG has been considered as a risk factor for obesity. The tastemakers in Chinese and fast foods, such as fish sauce and soy sauce, contain very high levels of glutamate.

View Article and Find Full Text PDF