Publications by authors named "Nandakumar T"

Article Synopsis
  • Pathological mutations in the Trk-fused gene (TFG) are linked to neurodegenerative diseases, particularly hereditary spastic paraplegia (HSP), causing lower limb issues.* -
  • Researchers used X-ray crystallography and cryo-electron microscopy to reveal how TFG forms octameric ring complexes, crucial for its function.* -
  • Mutations from HSP patients disrupt the stability of these complexes, leading to neurodegenerative effects, but different mutations have varying impacts, indicating multiple mechanisms of disease progression.*
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Article Synopsis
  • Switching to natural gas, particularly Liquefied Natural Gas (LNG) and Compressed Natural Gas (CNG), presents a viable solution for reducing CO emissions and air pollutants compared to traditional petroleum fuels.
  • Research focuses on the storage and transportation of methane (CH), which has a favorable C-H ratio for combustion and a lower environmental impact, making porous materials like covalent organic frameworks (COFs) important in this field.
  • The study reports successful scalable synthesis of two COFs, Tp-Azo and Tp-Azo-BD(Me), with significant surface areas and stable methane storage capacities, indicating their potential for safe gas storage at room temperature and pressure.
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To describe the ischemic stroke subtypes related to coronavirus disease 2019 (COVID-19) in a cohort of New York City hospitals and explore their etiopathogenesis. Most neurological manifestations are non-focal, but few have reported the characteristics of ischemic strokes or investigated its pathophysiology. Data were collected prospectively April 1-April 15, 2020 from two centers in New York City to review possible ischemic stroke types seen in COVID-19-positive patients.

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Introduction: Guillain Barré Syndrome (GBS) is an acute immune-mediated polyneuropathy most frequently presenting two to four weeks after an acute mild-moderately severe infection as progressive muscular weakness of the lower limbs extending proximally with dysreflexia and autonomic dysfunction. While GBS is typically believed to be isolated to the Peripheral Nervous System, Central Nervous System (CNS) and psychiatric manifestations as a sequela of the disease have been described in different imaging and clinical studies. Many variants of presentation of GBS have been recognized, however a case presenting with primarily psychiatric and autonomic dysfunction preceding muscle weakness has not been cited in the literatures to date.

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Background: Despite the high and relatively stable overall growth of the economy, India's agriculture sector is underperforming and a vast section of the population remains undernourished.

Objective: To explore the possible interplay between agricultural performance and malnutrition indicators to see whether states that perform better in agriculture record better nutritional outcomes.

Methods: Correlation analysis and a simple linear regression model were used to study the relationship between agricultural performance and malnutrition among children under 5 years of age and adults from 15 to 49 years of age at 20 major states using data from the National Family Health Survey-3 for the year 2005/06 and the national accounts.

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A bezoar is an accumulation of indigestible exogenous matter in the stomach and intestine. A myriad of ingested substances have been found impacted in the digestive tract. Bezoars are uncommon causes of intestinal obtruction during childhood.

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Myasthenia gravis (MG) is a chronic neuromuscular disease which leads to varying degrees of weakness in the skeletal muscles. Some of the symptoms of the disorder include weakness of the eye muscles, difficulty in swallowing and slurred speech. When only the muscles of the eyes are affected, the illness is termed ocular myasthenia, which is often characterized by abrupt onset of diplopia and ptosis of the eyelid.

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