The -Butanol Extract Obtained from the Inner Bark of (Bertol.) DC, Specioside, and Catalposide Induce Leukemia Cell Apoptosis in the Presence of Apicidin.

The cell signaling pathways involved in the antiproliferative activities of inner bark remain unexplored. This study evaluated the apoptotic effects of two iridoids from the inner bark of and apicidin on THP-1 cells. The cytotoxic effects of the extract and the pure compounds on THP-1 and Jurkat cells were also evaluated using the MTT assay.