Publications by authors named "Nancy Soto"

Article Synopsis
  • * It aims to create a practical toolkit for investigators within the NRG Oncology group to improve patient recruitment throughout the trial process, using engagement strategies and social media.
  • * The pilot of this toolkit in the NRG/Alliance NRG-LU005 trial for lung cancer resulted in exceeding enrollment targets, with many ongoing trials already utilizing elements from the toolkit.
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Background: The National Cancer Institute (NCI) organized the Operational Efficiency Working Group in 2008 to develop recommendations for improving the speed with which NCI-sponsored clinical trials move from the idea stage to a protocol open to patient enrollment.

Methods: Given the many stakeholders involved, the Operational Efficiency Working Group advised a multifaceted approach to mobilize the entire research community to improve their business processes. New staff positions to monitor progress, protocol-tracking Web sites, and strategically planned conference calls were implemented.

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In this work four spectrofluorimetric methods for the determination of irinotecan (CPT-11) in human urine and pharmaceuticals have been developed. Initially, the fluorescent characteristics of irinotecan (CPT-11) have been studied in both acidic and basic media. Later, the fluorescence emission generated by the oxidation of CPT-11 with several agents was studied.

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