Short-term stretch translocates the alpha-1-subunit of the Na pump to plasma membrane.

Short-term (2 30 min) cyclic stretch activates the Na pump in cultured aortic smooth muscle cells (ASMCs). This effect of stretch involves the phosphotidylinositol 3-kinase (PI 3-kinase) participation. Presently, we investigated whether this stimulation is the result of translocation of Na(+),K(+)-ATPase from endosomes to the plasma membrane.