Moderate-carbohydrate low-fat versus low-carbohydrate high-fat meal replacements for weight loss.

Objectives: To compare the efficacy of a low-carbohydrate high-fat versus a moderate-carbohydrate low-fat diet for weight loss and cardiovascular risk reduction.

Methods: In a prospective clinical trial, 137 participants (body mass index >or=25 kg/m2) were randomly assigned to Control (46 randomized, 44 completed), Low Carbohydrate (45 randomized, 42 completed), or Moderate Carbohydrate (46 randomized, 40 completed) groups. Outcomes included measures of body size and composition and blood chemistries.