Immunomodulatory Therapy for MIS-C.

Context: Studies comparing initial therapy for multisystem inflammatory syndrome in children (MIS-C) provided conflicting results.

Objective: To compare outcomes in MIS-C patients treated with intravenous immunoglobulin (IVIG), glucocorticoids, or the combination thereof.

Data Sources: Medline, Embase, CENTRAL and WOS, from January 2020 to February 2022.

Comparison of test-negative and syndrome-negative controls in SARS-CoV-2 vaccine effectiveness evaluations for preventing COVID-19 hospitalizations in the United States.

Background: Test-negative design (TND) studies have produced validated estimates of vaccine effectiveness (VE) for influenza vaccine studies. However, syndrome-negative controls have been proposed for differentiating bias and true estimates in VE evaluations for COVID-19. To understand the use of alternative control groups, we compared characteristics and VE estimates of syndrome-negative and test-negative VE controls.

A Bayesian ensemble approach to combine PM estimates from statistical models using satellite imagery and numerical model simulation.

Ambient fine particulate matter less than 2.5 μm in aerodynamic diameter (PM) has been linked to various adverse health outcomes. PM arises from both natural and anthropogenic sources, and PM concentrations can vary over space and time.

Satellite-Based Daily PM Estimates During Fire Seasons in Colorado.

The western United States has experienced increasing wildfire activities, which have negative effects on human health. Epidemiological studies on fine particulate matter (PM) from wildfires are limited by the lack of accurate high-resolution PM exposure data over fire days. Satellite-based aerosol optical depth (AOD) data can provide additional information in ground PM concentrations and has been widely used in previous studies.

The sensitivity of satellite-based PM estimates to its inputs: Implications to model development in data-poor regions.

Exposure to fine particulate matter (PM) has been associated with a wide range of negative health outcomes. The overwhelming majority of the epidemiological studies that helped establish such associations was conducted in regions with sufficient ground observations and other supporting data, i.e.