Deletion of histone demethylase (Kdm1a) during retinal development leads to defects in retinal function and structure.

Purpose: The purpose of this study was to investigate the role of Lysine specific demethylase 1 () in murine retinal development. LSD1 is a histone demethylase that can demethylate mono- and di-methyl groups on H3K4 and H3K9. Using Chx10-Cre and Rho-iCre75 driver lines, we generated novel transgenic mouse lines to delete in most retinal progenitor cells or specifically in rod photoreceptors.

Pathologic findings in postmortem corneas after successful laser in situ keratomileusis.

Purpose: To examine the histologic and ultrastructural features of human corneas after successful laser in situ keratomileusis (LASIK).

Methods: Corneas from 48 eyes of 25 postmortem patients were processed for histology and transmission electron microscopy (TEM). The 25 patients had LASIK between 3 months and 7 years prior to death.

Histologic and ultrastructural findings in human corneas after successful laser in situ keratomileusis.

Objective: To examine the histologic and ultrastructural features of human corneas after successful laser in situ keratomileusis (LASIK) in 2 patients post mortem.

Methods: Portions of 4 corneas were processed for histology, transmission electron microscopy, and scanning electron microscopy.

Results: Case 1 had undergone LASIK 3 months prior to death and case 2 had undergone LASIK 20 months prior to death.