The NCI's Cancer Information Service Staff Training Program: a foundation for excellence.

The philosophy of the National Cancer Institute's (NCI) Cancer Information Service (CIS) staff training program is based on the premise that a solid relationship exists between staff performance and training. As a leading edge organization and the premiere cancer information service in the world, the CIS provides more training to its staff than many organizations. This factor is in part responsible for the program's success over the past 30 years, during which time the staff training program was revised to reflect a more comprehensive, performance-based approach.

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists.

A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT(6) receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT(6) receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.

Spending and service use among people with the fifteen most costly medical conditions, 1997.

This study addresses the Institute of Medicine's recommendation that AHRQ use MEPS data to identify a set of priority conditions to inform efforts at improving quality of care. Using MEPS data we identify the fifteen most expensive conditions in the U.S.