Developmental plasticity allows outside-in immune responses by resident memory T cells.

Central memory T (T) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (T) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated T cells rejoined the circulating pool.

CD4 resident memory T cells dominate immunosurveillance and orchestrate local recall responses.

This study examines the extent to which memory CD4 T cells share immunosurveillance strategies with CD8 resident memory T cells (T). After acute viral infection, memory CD4 T cells predominantly used residence to survey nonlymphoid tissues, albeit not as stringently as observed for CD8 T cells. In contrast, memory CD4 T cells were more likely to be resident within lymphoid organs than CD8 T cells.

IFN-β Selectively Inhibits IL-2 Production through CREM-Mediated Chromatin Remodeling.

IFN-β is widely used in the treatment of multiple sclerosis, yet the mechanism facilitating its efficacy remains unclear. IL-2 production by activated T cells, including those mediating autoimmunity, and subsequent autocrine stimulation is vital for T cell expansion and function. In this study, we demonstrate that in mouse and human T cells, IFN-β specifically inhibits the production of IL-2 upon TCR engagement without affecting other cytokines or activation markers.