Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis.

Background: Appendiceal cancers are rare and consist of carcinoid, mucocele, pseudomyxoma peritonei (PMP), goblet cell carcinoma, lymphoma, and adenocarcinoma histologies. Current treatment involves surgical resection or debulking, but no standard exists for adjuvant chemotherapy or treatment for metastatic disease.

Methods: Samples were identified from approximately 60,000 global tumors analyzed at a referral molecular profiling CLIA-certified laboratory.

Monitoring Cardiac Patients: How Much Is Enough?

In brief ECG monitoring is generally recommended for patients in cardiac rehabilitation, but the optimal amount of monitoring is uncertain. This article reviews several questions regarding this issue. The authors conclude that monitoring during exercise testing is necessary to determine an appropriate exercise prescription for all cardiac patients, but additional monitoring is not indicated during upper extremity as opposed to lower extremity exercise.