Publications by authors named "Nancy Ann Dawson"
Article Synopsis
- Metastases, which are the spread of cancer cells to different organs, play a crucial role in the severity of renal cell carcinoma (RCC), with common sites being the lungs, bones, liver, and lymph nodes.
- This study analyzed 657 tumor samples from both primary renal tumors and various metastatic sites to identify genomic and transcriptomic differences.
- The findings reveal significant variations in tumor characteristics and the tumor microenvironment across different metastatic locations, highlighting the importance of these factors in creating targeted cancer treatments.
Background: Castration resistance occurs in most patients with metastatic hormone-sensitive prostate cancer who are receiving androgen-deprivation therapy. Replacing androgens before progression of the disease is hypothesized to prolong androgen dependence.
Methods: Men with newly diagnosed, metastatic, hormone-sensitive prostate cancer, a performance status of 0 to 2, and a prostate-specific antigen (PSA) level of 5 ng per milliliter or higher received a luteinizing hormone-releasing hormone analogue and an antiandrogen agent for 7 months.