Publications by authors named "Nancy Aloysius"
Article Synopsis
- Interictal epileptiform discharges are abnormal brain signals occurring between seizures that can help in diagnosing epilepsy through EEG tests.
- In a mouse study of kindling-induced seizures, researchers found an increase in interictal spikes rates prior to the onset of spontaneous recurrent seizures, while other brain patterns remained unchanged.
- The findings suggest that higher rates of interictal spikes and lower delta and theta rhythms in the hippocampus are linked to the development of spontaneous recurrent seizures in this model.
Convulsive behaviors of spontaneous recurrent seizures in a mouse model of extended hippocampal kindling.
Front Behav Neurosci
December 2022
Growing studies indicate that vigilance states and circadian rhythms can influence seizure occurrence in patients with epilepsy and rodent models of epilepsy. Electrical kindling, referred to brief, repeated stimulations of a limbic structure, is a commonly used model of temporal lobe epilepsy. Kindling the classic protocol lasting a few weeks does not generally induce spontaneous recurrent seizures (SRS), but extended kindling that applies over the course of a few months has shown to induce SRS in several animal species.
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