Publications by authors named "Nancy A Kerner"
Article Synopsis
- This study focused on developing composite scores for two new cognitive assessments aimed at early-stage Alzheimer's disease (AD) to evaluate their effectiveness and compare them with traditional measures.
- Researchers analyzed data from 291 older adults to assess the reliability and validity of the new assessments, utilizing exploratory factor analyses to understand their structure.
- The findings indicated that the new measures, No Practice Effect (NPE) and Miami Computerized Functional Skills Assessment, have superior psychometric properties and stronger links to AD risk markers, suggesting their potential use in clinical trials for early Alzheimer's detection.
Background: Mild cognitive impairment (MCI) increases the risk of dementia. The efficacy of cognitive training in patients with MCI is unclear.
Methods: In a two-site, single-blinded, 78-week trial, participants with MCI - stratified by age, severity (early/late MCI), and site - were randomly assigned to 12 weeks of intensive, home-based, computerized training with Web-based cognitive games or Web-based crossword puzzles, followed by six booster sessions.
Objectives: To evaluate the impact of obstructive sleep apnea (OSA) on neurocognitive function and brain morphology in older adults with depression and cognitive impairment.
Methods: We prospectively screened OSA with the STOP-Bang questionnaire in the last 25 patients enrolled into the Donepezil Treatment of Cognitive Impairment and Depression (DOTCODE) trial. High and low probability of OSA were defined as a STOP-Bang score of ≥5 (h-OSA) and of <5 (l-OSA), respectively.
Obstructive Sleep Apnea is Linked to Depression and Cognitive Impairment: Evidence and Potential Mechanisms.
Am J Geriatr Psychiatry
June 2016
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein the authors review studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiologic mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation.
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