Publications by authors named "Nanami Namba"
Acetaminophen (APAP) overdoses can cause severe liver injury. In this study, the protective effect of fasudil against APAP-induced liver injury was investigated. APAP (400 mg/kg) was administered to male C57BL/6J mice to induce liver injury, and fasudil (20 or 40 mg/kg) was injected 30 min before APAP administration.
View Article and Find Full Text PDFArticle Synopsis
- * A new treatment option, mono-6-O-α-maltosyl-γ-CD (G2-γ-CD), shows promise for NPC by reducing disease symptoms in mouse models and having less ototoxicity compared to the current option, HP-β-CD.
- * Research indicates that G2-γ-CD forms a more stable 1:1 cholesterol complex, unlike HP-β-CD, which forms a 2:1 complex at higher concentrations; this difference could explain its better safety profile and effectiveness for clinical use.
An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is administered. This study evaluated the protective effect of mitochondria-specific Mito-TEMPO (Mito-T) on APAP-induced acute liver injury in C57BL/6J male mice, and a three dimensional (3D)-cell culture model containing the human hepatoblastoma cell line HepG2.
View Article and Find Full Text PDF