Publications by authors named "Nanami Goda"
Article Synopsis
- The Hippo pathway is essential for regulating cell growth and differentiation, playing a key role in tumor development and embryonic formation.
- Scaffold proteins from the ERM family, particularly NF2 (Merlin), influence this pathway through cell polarity, but how this works for outer cell establishment is not fully understood.
- This study created specific Nf2 mutants to investigate its impact on YAP1 localization, revealing that NF2's positioning around the cell membrane affects cell polarity and the Hippo pathway's function by regulating the placement of proteins like LATS2 and ezrin.
A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is governed by cell position-dependent Hippo signaling, which is a phosphorylation cascade determining whether Yes-associated protein 1 (YAP1), one of the key components of the Hippo signaling pathway, localizes within the nucleus or cytoplasm. YAP1 localization determines the transcriptional on/off switch of a key gene, Cdx2, required for TE differentiation.
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