Publications by authors named "Nanaka Morita"
Article Synopsis
- The study investigates the diversity of Helicobacter pylori populations and how this heterogeneity affects its ability to cause diseases and resist treatment.
- Researchers tested four antibiotics on samples from 42 Japanese patients, discovering that over 60% exhibited a mix of drug-resistant and sensitive strains.
- The findings suggest that resistance patterns differ between treatment-naïve patients and those who failed previous treatment, highlighting the importance of analyzing multiple stomach isolates to better understand H. pylori infection.
Article Synopsis
- Sepsis is a severe inflammatory response caused by bacterial infections, particularly affecting the elderly, leading to high mortality; antibiotic overuse has resulted in multidrug-resistant bacteria.
- The study explores the role of CD8+ regulatory T cells (Tregs) in young versus aged mice during sepsis, finding that CD8+ Tregs from young mice improve survival rates after endotoxic shock.
- The research suggests that enhancing CD8+ Tregs through IL-15 treatment in aged mice can prevent weight loss and tissue damage, positioning this strategy as a potential immunotherapy for improving sepsis outcomes.
Various cancer cells require massive amounts of glucose as an energy source for their dysregulated growth. Although D‑allose, a rare sugar, inhibits tumor cell growth via inhibition of glucose uptake, a few cells can survive after treatment. However, the mechanism by which D‑allose‑resistant cells are generated remains unclear.
View Article and Find Full Text PDFDiffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy that is the most common type of lymphoma in Japan. Previous studies have demonstrated that patients with DLBCL have a poor prognosis due to increased levels of indoleamine 2,3-dioxygnase and kynurenine (KYN). However, the roles of metabolites acting downstream of KYN and associated enzymes are not fully understood.
View Article and Find Full Text PDFKynurenine (Kyn) plays an important role as an immune check-point molecule and regulates various immune responses through its aryl hydrocarbon receptor (Ahr). Kyn is synthesized by indoleamine 2,3-dioxygenase (Ido) and tryptophan 2,3-dioxygenase (Tdo). Ido contributes approximately 90% of tryptophan catabolism.
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