Publications by authors named "Nana-Ayisha Yakubu"

Background: More than one-third of all diseases in the world are non-communicable diseases (NCDs), and poorer health outcomes are linked to low health literacy (HL), in which nurses have a significant role to play. Various studies have confirmed that there is an association between HL and NCDs. However, less is known about how nurses can intervene in the development of HL in patients with NCDs.

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Mechanical thrombectomy (MT) has revolutionized the management of proximal large vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS), improving long-term outcomes compared to standard treatments. However, despite its success in high-income countries, the widespread implementation of MT in Africa remains limited. With Africa experiencing one of the highest stroke burdens globally, this study examines the barriers impeding the adoption of MT in the region.

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The twin testosterone transfer (TTT) hypothesis posits that females with male co-twins (opposite-sex, OS) might develop male-typical traits due to higher prenatal testosterone exposure. This study explored whether females of OS have lower 2D:4D digit ratios and higher testosterone levels compared to females of same-sex (SS) twin pairs. Conducted in Tamale from January to December 2022, the study included 40 participants aged 18-27 years: 10 males of OS, 10 females of OS, and 20 females of SS twin pairs.

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Background: Beyond physical health, managing type 1 diabetes (T1D) also encompasses a psychological component, including diabetes distress, that is, the worries, fears, and frustrations associated with meeting self-care demands over the lifetime. While digital health solutions have been increasingly used to address emotional health in diabetes, these technologies may not uniformly meet the unique concerns and technological savvy across all age groups.

Objective: This study aimed to explore the mental health needs of adolescents with T1D, determine their preferred modalities for app-based mental health support, and identify desirable design features for peer-delivered mental health support modeled on an app designed for adults with T1D.

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Objective: To assess the prevalence of non-utilisation of postpartum services in northwestern Nigeria from 2003 to 2018 and to identify and estimate the influence of social determinants, a crucial step in improving maternal and child health in the region.

Design: The 2003, 2008, 2013 and 2018 Nigeria Demographic and Health Survey rounds were used. Descriptive, trend and multivariable logistic regression analyses were used to show the trend and assess the influence of social determinants.

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Catatonia is a complex neuropsychiatric syndrome characterised by abnormal psychomotor disturbance, which poses a diagnostic and treatment challenge to clinicians. It is a life-threatening condition in its severe form, termed malignant and characterised by hyperthermia and autonomic disturbances. Early recognition and treatment are important in its management.

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Objectives: The burgeoning prevalence of cardiometabolic disorders, including type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) within Africa is concerning. Machine learning (ML) techniques offer a unique opportunity to leverage data-driven insights and construct predictive models for MetS risk, thereby enhancing the implementation of personalised prevention strategies. In this work, we employed ML techniques to develop predictive models for pre-MetS and MetS among diabetic patients.

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Article Synopsis
  • There is an increasing focus on ethical challenges in genomics research for Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) due to the vulnerabilities of study participants.
  • A systematic review of 5,509 papers narrowed down to 27 relevant studies, uncovering 109 ethical issues categorized under a framework addressing ethical principles specific to AD/ADRD research.
  • The review highlights a lack of literature on critical ethical principles like "fair participant selection" and "social value," suggesting a need for more comprehensive research on these topics in various socioeconomic contexts.
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Background: The first line of care is a paramount stage in the management of the mentally ill persons. In Nigeria, traditional and faith-based healers compete with medical professionals in providing care.

Aim: Pathway to care among patients with Mental Illness at Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria.

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  • Specific phobic anxiety disorder involves excessive fear of specific objects or situations, leading to significant distress and dysfunction in daily life.
  • A case study detailed the experience of an adult woman with a rare phobia of hedgehogs, diagnosed as skatzochoirophobia, who was treated successfully through systematic desensitization.
  • The findings highlight the importance of awareness among clinicians for early detection and intervention of this uncommon phobia.
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Background: Sickle cell disease (SCD) is highly prevalent in Africa, especially in Nigeria, the most populous country, and is associated with a high mortality rate. Depression, common among individuals with SCD, correlates with increased pain intensity and opioid misuse, leading to poorer outcomes and diminished quality of life in these patients.

Aim: To determine whether major depressive disorder is a predictor of opioid use disorder among patients with sickle cell disease.

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Despite consistent evidence highlighting the benefits of exclusive breastfeeding (EBF) for the first six months, EBF duration sometimes falls short of six months or exceeds it. This research seeks to explore factors influencing the practice of optimal duration of EBF and identify factors associated with suboptimal EBF durations. A cross-sectional survey was conducted in 16 districts across four Northern regions of Ghana with 2000 caregivers of children under five years old.

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This study investigates the predictors of consistent condom use among male construction workers in South Africa who reported concurrent sexual relationships with regular partners, casual partners, and sex workers over a 3-month period. A cross-sectional survey was used to collect data from a convenience sample of 450 male workers across 18 construction work sites in the Western Cape province. Of these, 245 (54%) indicated that they had engaged in sex with all three partner types during the 3-month study period.

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Article Synopsis
  • - This study explores the impact of Bisphenol A (BPA), an endocrine disruptor known to affect male fertility, on the testicular mitochondria of male albino rats and tests the protective effects of seed oil (CMSO).
  • - Six groups of rats were used, with varying doses of BPA and CMSO; the study measured mitochondrial enzyme activity, membrane potential, protein levels, and body weight post-exposure.
  • - Results showed that BPA reduced key mitochondrial activities and rat body weight, but coadministration of CMSO helped restore these disrupted functions, suggesting CMSO could be a potential treatment for toxins like BPA.
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Hepatocellular carcinoma (HCC) is a disease of public health concern in Nigeria, with chronic hepatitis B and C infections contributing most to the disease burden. Despite the increasing incidence of HCC, surveillance practices for early diagnosis and possible cure are not deeply rooted in the country. This article aims to review the current status of HCC surveillance in Nigeria, stressing the encounters, breaches, and potential prospects.

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Purpose Of Review: To explore the impact of digitally-enabled peer support interventions on diabetes distress and depression for individuals living with Type 1 Diabetes (T1D).

Recent Findings: We synthesized the results of nine key studies from a review of 3,623 English-language articles published between January 2012 and January 2024. Three studies demonstrated significant reductions in diabetes distress, and two studies reported reductions in depression.

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Article Synopsis
  • Rapid urbanization in sub-Saharan Africa is linked to a rise in asthma cases among children and teens, particularly due to challenges in obtaining clinical diagnoses for those exhibiting symptoms.* -
  • A two-phase study was conducted across multiple countries involving adolescents aged 12-14, where asthma symptoms were assessed through a questionnaire, and further evaluations were carried out on those with symptoms, including tests for lung function and environmental risk factors.* -
  • The study aimed to gather data on the prevalence and severity of asthma in symptomatic adolescents, alongside objective testing methods like spirometry and fractional exhaled nitric oxide (FeNO) to better understand asthma's impact on daily life.*
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Enhancing the endurance and efficiency of polymer electrolyte membrane fuel cells (PEMFCs) requires efficient thermal management. This comprehensive review examines the primary cooling techniques employed in PEMFC systems, concentrating on techniques for air and liquid cooling. Liquid cooling, which circulates a coolant through channels adjacent to the ability of the fuel cell stack to maintain ideal operating temperatures, is highlighted and significantly reduces temperature variations, thereby improving overall efficiency and lifespan.

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Objectives: To investigate the association between the extent of nocturnal systolic blood pressure decline and left ventricular hypertrophy in patients with primary hypertension who were receiving antihypertensive drug therapy.

Design: This was a cross-sectional hospital-based study from November 2020 to March 2021.

Setting: The study was conducted at the Polyclinic of Korle Bu Teaching Hospital, Ghana.

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Article Synopsis
  • A scoping review examined ethics regulations for Alzheimer's Disease (AD) and Alzheimer's Disease-Related Disorders (ADRD) research in Africa, using a specific framework to analyze the landscape.
  • The review covered regulations from 14 African countries published between 1997 and 2020, highlighting that most regulations require the appointment of Legally Authorised Representatives to protect individuals with AD/ADRD.
  • The study found that detailed provisions for capacity assessments and advance directives were limited, and no country referenced the Convention on the Rights of Persons with Disabilities, indicating a lack of specific and practical ethical guidelines for AD/ADRD research in Africa.
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Introduction: Vancomycin-resistant Enterococci (VRE) infections cause significant morbidity and mortality in liver transplant (LT) recipients. Management is challenging, especially in the setting of daptomycin resistance (DR).

Methods: Single-center retrospective review of patients who underwent LT between January 1, 2020, and December 31, 2022, and developed VRE infections.

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  • Dyslipidaemia is a major contributor to coronary artery disease (CAD) and cardiovascular issues globally, and understanding statin benefits is essential for its effective management.
  • A web-based survey involving 313 physicians in Nigeria revealed that while most recognize elevated LDL-C as a key cause of CAD, many have concerns about statin side effects and their impact on patient adherence.
  • The findings indicate significant knowledge and practice gaps in dyslipidaemia management among Nigerian physicians, suggesting a need for improvement initiatives to reduce cardiovascular risk.
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  • Anthonotha macrophylla is a plant known for its various ethnomedicinal uses, including treating venereal diseases, intestinal discomfort, and enhancing sexual behavior, especially noted for scientific validation in female rats but lacking studies in male rat models with sexual dysfunction.* -
  • The study aimed to explore the aphrodisiac effects of an aqueous extract from Anthonotha macrophylla leaves in male rats experiencing paroxetine-induced sexual dysfunction.* -
  • Results indicated that the extract was rich in minerals and amino acids, and paroxetine negatively impacted sexual behavior, suggesting the need for further analysis on the extract’s potential benefits for male sexual health.*
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  • Measles and rubella micro-array patches (MR-MAPs) are innovative alternatives to traditional needle and syringe vaccines, offering single-dose convenience, easier handling, and better temperature stability.
  • An initial full value vaccine assessment (iFVVA) evaluated their potential impact, finding that widespread use of MR-MAPs could prevent millions of measles cases, deaths, and years lost to disability by reaching an additional 80 million children over the next decade.
  • The assessment also emphasized the need for financial investment in manufacturing and clinical studies, while showing that MR-MAPs have the potential to be cost-effective for routine immunization in many low- and middle-income countries, depending on pricing and coverage uncertainties.*
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