A systematic review of heavy metals contamination in cosmetics.

Globally, the consumption and use of cosmetics have increased exponentially. The presence of hazardous metals raises worries about their potential long-term impacts on human health. This review's primary goal is to shed light on the presence and ranges of heavy metal concentrations in diverse cosmetic samples as well as the instrumental techniques used by various authors to analyse the hazardous metals in the articles under evaluation.

Paradoxical responses after start of antimicrobial treatment in Mycobacterium ulcerans infection.

Background:  Antimicrobial killing in mycobacterial infections may be accompanied by (transient) clinical deterioration, known as paradoxical reaction. To search for patterns reflecting such reactions in the treatment of Buruli ulcer (Mycobacterium ulcerans infection), the evolution of lesions of patients treated with antimicrobials was prospectively assessed.

Methods:  The lesion size of participants of the BURULICO antimicrobial trial (with lesions ≤10 cm cross-sectional diameter) was assessed by careful palpation and recorded by serial acetate sheet tracings.