Background: Sodium intake reduction is crucial for cardiovascular health, however, its lasting impact on dementia remains unclear.
Methods: We included 458,577 UK Biobank participants without dementia at baseline. We estimated 24-h urinary sodium (E24hUNa) using spot urinary parameters and obtained the incidence of all-cause dementia, Alzheimer's disease, and vascular dementia from multiple sources.
We introduce MolPhase, an advanced algorithm for predicting protein phase separation (PS) behavior that improves accuracy and reliability by utilizing diverse physicochemical features and extensive experimental datasets. MolPhase applies a user-friendly interface to compare distinct biophysical features side-by-side along protein sequences. By additional comparison with structural predictions, MolPhase enables efficient predictions of new phase-separating proteins and guides hypothesis generation and experimental design.
View Article and Find Full Text PDFBased on the online monitoring data of volatile organic compounds(VOCs) and ozone(O) in Liaocheng in June 2021, the concentration levels, compositional characteristics, daily variation characteristics, and ozone formation potential(OFP) of VOCs on polluted days and clean days were systematically analyzed. Potential source areas of VOCs were identified by the potential source contribution function(PSCF) and concentration-weighted trajectory(CWT). The sources of VOCs in Liaocheng were analyzed using the characteristic species ratio and positive matrix factorization(PMF).
View Article and Find Full Text PDFBackground: Chronic renal disease (CKD) is a common and irreversible loss of renal function. Renal fibrosis reflected the degree of renal dysfunction. However, the current biomarkers only characterize the renal function instead of indicating the fibrosis degree.
View Article and Find Full Text PDFBackground: The non-invasive identification of novel renal fibrosis biomarkers needs to be further studied.
Methods: We collected urine samples from 77 biopsy-proven CKD patients and 15 healthy controls. The expression of urinary TREM-1 and TREM-2 was measured and the correlation with renal function parameter and pathological indicators was performed.
Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Circular RNAs (circRNAs) are involved in regulating various biological processes. This study aimed to explore the role and molecular basis of hsa_circ_0006872 in cigarette smoke extract (CSE)-induced cell injury.
View Article and Find Full Text PDFSite U1489 was drilled during the International Ocean Discovery Program (IODP) Expedition 363 and is located on the western slope of the southern Eauripik Rise (2.12°N, 141.03°E, 3421 m water depth).
View Article and Find Full Text PDFJ Hazard Mater
March 2019
Polycyclic aromatic hydrocarbons (PAHs) have enormous potential hazards. It is necessary for China to propose more internationally stricter standards for PAHs, in order to improve the country's pollutant prevention and control policy system, and ultimately, provide institutional guarantees for implementing PAH emissions prevention and control. In this study, phenanthrene, a typical PAHs generated during municipal solid waste (MSW) to energy system, was applied as a model compound to study the thermal degradation mechanism during the combustion process.
View Article and Find Full Text PDFThe heavy metals distribution during hydrothermal carbonization (HTC) of sewage sludge, and pyrolysis of the resultant hydrochar was investigated and compared with raw sludge pyrolysis. The results showed that HTC reduced exchangeable/acid-soluble and reducible fraction of heavy metals and lowered the potential risk of heavy metals in sewage sludge. The pyrolysis favored the transformation of extracted/mobile fraction of heavy metals to residual form especially at high temperature, immobilizing heavy metals in the chars.
View Article and Find Full Text PDFThinopyrum ponticum (Th. ponticum) (2n = 10x = 70) is an important breeding material with excellent resistance and stress tolerance. In this study, we characterized the derivative line CH1113-B13-1-1-2-1 (CH1113-B13) through cytological, morphological, genomic in situ hybridization (GISH), fluorescence in situ hybridization (FISH), expressed sequence tag (EST), and PCR-based landmark unique gene (PLUG) marker analysis.
View Article and Find Full Text PDFThe heteroatoms (N and S) doped porous carbons (HAPCs) were prepared from sewage sludge by hydrothermal carbonization and chemical activation for the first time. The porous structures and surface properties of HAPCs were characterized by multiple techniques including SEM-EDS, TEM, BET, XRD, Raman spectroscopy and Boehm's titration. The resultant materials were showed to be naturally N and S dual-doped porous carbons (HAPCs), especially for HAPC obtained by HCl-HF-washing, which was typical 3D hierarchically porous structure with abundant mesopores as well as big pore diameter.
View Article and Find Full Text PDFLeymus mollis (Trin.) Pilg. (2n = 4x = 28, NsNsXmXm) possesses a number of valuable genes against biotic and abiotic stress, which could be transferred into common wheat background for wheat improvement.
View Article and Find Full Text PDFA highly graphitized and heteroatom doped porous carbon was prepared from fish waste in the present study. The morphology and chemical composition of the resultant porous carbon were characterized by SEM-EDS, TEM, BET, XRD and Raman measurement. The prepared porous carbon was employed as an adsorbent for acid orange 7, a typical azo dye, removal from aqueous solution.
View Article and Find Full Text PDFEmission and distribution characteristics of polycyclic aromatic hydrocarbons (PAHs) were investigated during municipal solid waste (MSW) and coal combustion alone and MSW/coal blend (MSW weight fraction of 25%) co-combustion within a temperature range of 500°C-900°C. The results showed that for all combustion experiments, flue gas occupied the highest proportion of total PAHs and fly ash contained more high-ring PAHs. Moreover, the 3- and 4-ring PAHs accounted for the majority of total PAHs and Ant or Phe had the highest concentrations.
View Article and Find Full Text PDFBioresour Technol
June 2015
This study investigated co-liquefaction of microalgae (Chlorella pyrenoidosa, CP) and lignocellulosic biomass (Rice husk, RH) in subcritical water for bio-oil production. The effects of liquefaction temperature (200-350°C), residence time (10-90min), solid concentration (10-30wt.%) and mass ratio of CP/RH on product distribution were investigated.
View Article and Find Full Text PDFThermogravimetric analysis and differential thermal analysis were employed to investigate combustion characteristics of two low-lipid microalgae, Chlorella pyrenoidosa (CP) and Spirulina platensis (SP) and iso-conversional Starink approach was used to calculate the kinetic parameters in the present study. The results showed that three stages of mass loss, including dehydration, devolatilization and char oxidation, were observed during combustion of both of two low-lipid microalgae. The whole weight loss of combustion of two microalgae was both shifted to higher temperature zones with increased heating rates from 10 to 40 K/min.
View Article and Find Full Text PDFBackground: The urokinase-type plasminogen activator receptor (uPAR) is an important regulator of ECM proteolysis, cell-ECM interactions and cell signaling. uPAR and heat shock proteins HSP70 and MRJ (DNAJB6) have been implicated in tumor growth and metastasis. We have reported recently that MRJ (DNAJB6, a heat shock protein) can interact with uPAR and enhance cell adhesion.
View Article and Find Full Text PDFBackground: Urokinase (uPA) and its receptor (uPAR) play an important role in tumour growth and metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumours. Targeting the excessive activation of this system as well as the proliferation of the tumour vascular endothelial cell would be expected to prevent tumour neovasculature and halt tumour development. The amino terminal fragment (ATF) of urokinase has been confirmed effective to inhibit the proliferation, migration and invasiveness of cancer cells via interrupting the interaction of uPA and uPAR.
View Article and Find Full Text PDFThe compound bioflocculant (CBF)-aluminum sulfate (AS) dual-coagulant and AS were comparatively studied for the coagulation of kaolin-humic acid solution. Floc properties including floc growth rate, size, strength, recoverability and fractal dimension under different pH conditions were investigated by Mastersizer 2000. Results indicated that, the flocs formed by AS-CBF (AS dosed first) showed the largest size and the best recoverability across the pH range investigated.
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