HOXD10 regulates intestinal permeability and inhibits inflammation of dextran sulfate sodium-induced ulcerative colitis through the inactivation of the Rho/ROCK/MMPs axis.

Ulcerative colitis (UC) has been identified as a severe inflammatory disease with significantly increased incidence across the world. The detailed role and mechanism of HOXD10 in UC remain unclear. In present study, we found that HOXD10 was lowly expressed in UC samples and was notably decreased by dextran sulfate sodium (DSS) administration.

Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice.

Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine whether Drp1 directly regulates skeletal muscle insulin sensitivity and whole-body glucose homeostasis.

Effectiveness of a combined problem-based learning and flipped classroom teaching method in ophthalmic clinical skill training.

Background: Previous studies have primarily implemented problem-based learning (PBL) or flipped classroom (FC) teaching models in different majors; however, research on the combined PBL-FC teaching method in clinical medicine is scarce. Therefore, we investigated the combined PBL-FC teaching method in teaching ocular trauma on students' competencies.

Method: About 75 ophthalmology postgraduates were randomly divided into PBL-FC and traditional teaching groups.

The Analysis of the Innovation Consciousness of College Student Entrepreneurs Under the Teaching Concept of Chinese Excellent Traditional Culture.

The purpose of this study was to analyze the current situation of the entrepreneurial consciousness of college student entrepreneurs and to explore the role of innovative and entrepreneurial talents in social and economic development. Based on the teaching concept of Chinese excellent traditional culture, first, the relevant theories of innovation and entrepreneurship, as well as the characteristics of entrepreneurial talents in colleges and entrepreneurs, are analyzed and elaborated; moreover, the definition of college student entrepreneur is explained; then, from the perspective of entrepreneurial teaching management, entrepreneurial education, and place support, the questionnaire method is selected to show the understanding of the entrepreneurship of college students; finally, based on the Cobb-Douglas function, the model before and after the introduction of innovative and entrepreneurial talents is tested and analyzed. Investigation and analysis suggest that most college students have entrepreneurial intention, and 61.

Comparative Genomics Revealing Insights into Niche Separation of the Genus .

The genus uses methanol as a carbon and energy source, which is widely distributed in terrestrial, freshwater and marine ecosystems. Here, three strains (13, 14 and QUAN) related to the genus , were newly isolated from Lake Fuxian sediments. The draft genomes of strains 13, 14 and QUAN were 3.

Orthokeratology and Low-Intensity Laser Therapy for Slowing the Progression of Myopia in Children.

Orthokeratology (OK) is widely used to slow the progression of myopia. Low-level laser therapy (LLLT) provides sufficient low energy to change the cellular function. This research is aimed at verifying the hypothesis that LLLT treatment could control myopia progression and comparing the abilities of OK lenses and LLLT to control the refractive error of myopia.

Subfoveal Choroidal Thickness in Myopia: An OCT-Based Study in Young Chinese Patients.

Myopia is a common cause of visual impairment worldwide. Choroidal thickness (ChT) reflects the characteristic changes in myopic children and may be used as an important index of myopia. The purpose of this study was to investigate ChT and its distribution across the posterior pole in young myopic Chinese patients using enhanced depth imaging optical coherence tomography (EDI-OCT) and to explore the factors associated with it.

Smad7 alleviates glomerular mesangial cell proliferation via the ROS-NF-κB pathway.

Objective: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-κB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation.

Methods: pAdTrack-CMV-Smad7 was transduced into rat GMC by adeno-transduction using an ADV (adenovirus)-mediated vector in vivo. Diphenylene iodonium chloride (DPI) pre-treated GMC, and blocked ROS generation as determined by DCFH-DA method.

Highly transparent and luminescent lanthanide ion-containing bridged polysilsesquioxanes.

Novel luminescent bridged polysilsesquioxane monoliths of high transparency have been obtained by hydrolysis and condensation of the precursor under acidic conditions. The monoliths were characterized by FTIR spectroscopy, photoluminescence spectroscopy, and SEM, and they have been used as hosts of Eu(3+), Tb(3+) and Nd(3+) ions. The luminescence lifetime of Tb(3+) in this host was 2.