Publications by authors named "Nana Kanda"
Article Synopsis
- The study focuses on understanding the function of the PmrAB two-component system (TCS) in resistance to colistin, a last-resort antibiotic, in extensively drug-resistant (XDR) Gram-negative bacteria.
- Researchers conducted transcriptome analysis to identify the regulatory genes controlled by PmrAB, revealing its responsiveness to environmental factors like pH and metal ions (Fe, Zn, Al).
- The findings highlight PmrAB's role in both environmental adaptation and the development of antibiotic resistance by modifying lipooligosaccharide (LOS) to mitigate toxicity and enhance resistance to colistin and polymyxin B.
Microbiol Spectr
October 2022
Article Synopsis
- * This study examined how colistin-resistant A. baumannii strains arise, showing that while colistin alone leads to LPS-deficient strains, combining it with other antibiotics results in strains with modified LPS.
- * The findings indicate that LPS-deficient strains are less fit and more susceptible to other treatments, suggesting that LPS-modified strains are more prevalent in clinical settings, highlighting the urgent need to address colistin resistance in healthcare.
