Evidences of the sources of suspended sediments and ecological processes in the Yellow River Basin.

Terrestrial originated suspended sediments from the Yellow River are crucial to understand the sources of the suspended sediment and ecological processes in estuary. This study integrated physicochemical indices, stable isotopes and microbial communities to trace the origin of the suspended sediment, and investigated the importance of ecological processes in community assembly via the null model and neutral community model. Global data revealed that the dissolved and particle ratios of carbon and nitrogen obviously decreased from the headstream to the estuary.

Nomograms for predicting recurrence of HER2-positive breast cancer with different HR status based on ultrasound and clinicopathological characteristics.

Purpose: This study aimed to identify ultrasound and clinicopathological characteristics related to recurrence in HER2-positive (HER2+) breast cancer, and to develop nomograms for predicting recurrence.

Methods: In this dual-center study, we retrospectively enrolled 570 patients with HER2+ breast cancer. The ultrasound and clinicopathological characteristics of hormone receptor (HR)-/HER2+ patients and HR+/HER2+ patients were analyzed separately according to HR status.

Noninvasive Abiotic Stress Phenotyping of Vascular Plant in Each Vegetative Organ View.

The last decades have witnessed a rapid development of noninvasive plant phenotyping, capable of detecting plant stress scale levels from the subcellular to the whole population scale. However, even with such a broad range, most phenotyping objects are often just concerned with leaves. This review offers a unique perspective of noninvasive plant stress phenotyping from a multi-organ view.

HYAL1 deficiency attenuates lipopolysaccharide-triggered renal injury and endothelial glycocalyx breakdown in septic AKI in mice.

Background: Renal dysfunction and disruption of renal endothelial glycocalyx are two important events during septic acute kidney injury (AKI). Here, the role and mechanism of hyaluronidase 1 (HYAL1) in regulating renal injury and renal endothelial glycocalyx breakdown in septic AKI were explored for the first time.

Methods: BALB/c mice were injected with lipopolysaccharide (LPS, 10 mg/kg) to induce AKI.

Research on the Visualization of Railway Signal Operation and Maintenance Based on BIM + GIS.

To adapt to the "fine" and "extensive" management characteristics of railway signal equipment operation and maintenance, achieving real-time and interactive monitoring of signal equipment operation status, and developing an integrated approach to equipment operation and maintenance, this paper takes a comprehensive management perspective. To create a lightweight BIM model, the Garland folding algorithm is utilized to simplify the IFC file format. Building on this approach, the data are divided based on building component division standards to obtain separate files containing geometric information and semantic attributes.

Survival benefit of anlotinib in T790M-positive non-small-cell lung cancer patients with acquired osimertinib resistance: A multicenter retrospective study and exploratory in vitro study.

Objectives: Acquired resistance represents a bottleneck to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in lung cancer. Our study aimed to explore the efficacy of antiangiogenic-based therapy in osimertinib-resistant NSCLC patients and assess the efficacy of anlotinib in vitro study.

Methods: Our multicenter study retrospectively collected 268 osimertinib-resistant NSCLC patients with EGFR T790M mutation and explored the efficacy of anlotinib in patients and in vitro.

Correlation of androgen receptor with ultrasound, clinicopathological features and clinical outcomes in breast cancer.

Background: This study aimed to explore whether there is an association between androgen receptor (AR) expression and ultrasound, clinicopathological features and prognosis of breast cancer.

Methods: A total of 141 breast cancer patients were included in this retrospective study. AR expression was analyzed by immunohistochemistry.

Feasibility of soil and sludge standards for freshwater sediment pollutant determination and quality judgment.

The environmental standards of soil and sludge have been typically referenced for freshwater sediment determination and quality assessment, especially in some areas without sediment standards. The feasibility of determination method and quality standard of soils and sludge for freshwater sediment was investigated in this study. Fractions of heavy metals, nitrogen, phosphorus, and reduced inorganic sulfur (RIS) in different type of samples were determined, including freshwater sediments, dryland and paddy soils, and sludge with air-drying (AD) and freeze-drying (FD) treatment, respectively.

Radiogenomic analysis of prediction HER2 status in breast cancer by linking ultrasound radiomic feature module with biological functions.

Background: Human epidermal growth factor receptor 2 (HER2) overexpressed associated with poor prognosis in breast cancer and HER2 has been defined as a therapeutic target for breast cancer treatment. We aimed to explore the molecular biological information in ultrasound radiomic features (URFs) of HER2-positive breast cancer using radiogenomic analysis. Moreover, a radiomics model was developed to predict the status of HER2 in breast cancer.

bta-miR-2904 inhibits bovine viral diarrhea virus replication by targeting viral-infection-induced autophagy via ATG13.

MicroRNAs (miRNAs) are endogenous small and noncoding RNA molecules (18-25 nt) that can regulate expression of their target genes post-transcriptionally. Previously, using high-throughput sequencing data obtained on a Solexa platform, we found that Bos taurus bta-miR-2904 (miR-2904) was significantly upregulated in Madin-Darby bovine kidney (MDBK) cells infected with bovine viral diarrhea virus (BVDV) strain NADL at 2, 6, and 18 h postinfection (hpi) compared to uninfected MDBK cells. Moreover, miR-2904 overexpression significantly reduced BVDV replication.

Overexpression of FAM83A Is Associated with Poor Prognosis of Lung Adenocarcinoma.

Family with sequence similarity 83, member A (FAM83A) plays an essential and fundamental role in the proliferation, progression, and apoptosis of many malignant tumors, including lung cancer. This study aimed to determine the expression pattern of FAM83A in lung adenocarcinoma (LUAD) and its correlation with the prognosis of cancer and the survival of the patients. Bioinformatics analysis, immunohistochemistry, and Western blotting were used to explore and detect the expression of FAM83A in LUAD cells.

Neoadjuvant Savolitinib targeted therapy stage IIIA-N2 primary lung adenocarcinoma harboring Exon 14 skipping mutation: A case report.

exon 14 skipping mutation (ex14m) is rare and occurs in approximately 1-4% of all non-small cell lung cancer (NSCLC) patients and approximately 2.8% of resected stage I-III NSCLC patients. Savolitinib is an oral, potent and highly selective type Ib inhibitor, which has been shown to be promising activity and acceptable safety profile in patients with advanced NSCLC harboring ex14m.

The performance of detecting Mycobacterium tuberculosis complex in lung biopsy tissue by metagenomic next-generation sequencing.

Background: Tuberculosis (TB) is a chronic infectious disease caused by the Mycobacterium tuberculosis complex (MTBC), which is the leading cause of death from infectious diseases. The rapid and accurate microbiological detection of the MTBC is crucial for the diagnosis and treatment of TB. Metagenomic next-generation sequencing (mNGS) has been shown to be a promising and satisfying application of detection in infectious diseases.

Nomograms predicting recurrence in patients with triple negative breast cancer based on ultrasound and clinicopathological features.

Objectives: The clinicopathological and ultrasound features associated with recurrence in patients with triple negative breast cancer (TNBC) were used to develop a nomogram to predict the prognosis of TNBC.

Methods: Clinicopathological data of 300 patients with TNBC treated between July 2012 and September 2014 were retrospectively reviewed. The endpoint was progression-free survival (PFS).

Effect of salinity on the determination of dissolved non-reactive phosphorus and total dissolved phosphorus in coastal waters.

The salinity may affect the phosphorus (P) determination accuracy in coastal waters, especially for the dissolved non-reactive P (DNRP) and total dissolved P (TDP). In this work, the competition mechanism between NaCl and DNRP for oxidants (K S O , the most commonly used and recognized oxidant) was identified in different DNRP determinations. Furthermore, salinity influences on determinations of tetrasodium pyrophosphate decahydrate, glyphosate, phytic acid sodium salt hydrate, adenosine-5'-nomophosphate disodium, and TDP were investigated.

Acute Respiratory Distress Syndrome Caused by Occupational Exposure to Waterproofing Spray: A Case Report and Literature Review.

Background: Acute respiratory distress syndrome (ARDS) is a serious respiratory disease, caused by severe infection, trauma, shock, inhalation of harmful gases and poisons and presented with acute-onset and high mortality. Timely and accurate identification will be helpful to the treatment and prognosis of ARDS cases. Herein, we report a case of ARDS caused by occupational exposure to waterproofing spray.

Immune Thrombocytopenia Induced by Immune Checkpoint Inhibitrs in Lung Cancer: Case Report and Literature Review.

Immune checkpoint inhibitors (ICIs), including antibodies targeting programmed cell death protein-1 (PD-1) and programmed cell death ligand-1 (PD-L1), are being extensively used on advanced human malignancies therapy. The treatment with ICIs have acquired durable tumor inhibition and changed the treatment landscape in lung cancer. Immune-related adverse events including pneumonitis and thyroiditis have been well described, but less frequent events, such as ICIs-induced thrombocytopenia, are now emerging and may sometimes be severe or fatal.

Right atrial papillary fibroelastoma arising from the Chiari network detected by echocardiography: a case report and literature review.

Purpose: To improve our understanding of cardiac papillary fibroelastomaand provide evidence for its treatment and prognosis.

Materials And Methods: We report a 54-year-old Chinese male who was hospitalized for a 14-day headache with a previous vertebral aneurysm history. A right atrial mass arising from the Chiari network was detected by echocardiography and complete tumor resection was performed finally.

Chemical compositions and repellent activity of Clerodendrum bungei Steud. essential oil against three stored product insects.

Background: Several species of Verbenaceae have been widely used in medicine, and some species of Verbenaceae have been observed good insecticidal activity, such as Lantana camara and Vitex negundo. There is no report about repellent activity of Clerodendrum bungei Steud. (C.

Genetic alteration of Chinese patients with rectal mucosal melanoma.

Background: Rectal mucosal melanoma (RMM) is a rare and highly aggressive disease with a poor prognosis. Due to the rarity of RMM, there are few studies focusing on its genetic mechanism. This retrospective study aimed to analyze the genetic spectrum and prognosis of RMM in China and lay a foundation for targeted therapy.

Biomarkers of Osimertinib Response in Patients with Refractory, EGFR-T790M-positive Non-Small Cell Lung Cancer and Central Nervous System Metastases: The APOLLO Study.

Purpose: Dynamic biomarker monitoring may inform pathways for treating -T790M-positive non-small cell lung cancer (NSCLC) and central nervous system (CNS) metastases with osimertinib. This study aimed to determine the efficacy and safety of osimertinib for real-world patients with -T790M NSCLC and CNS metastases and to explore potential circulating biomarkers of therapeutic response.

Patients And Methods: APOLLO (ClinicalTrials.