LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways.

Aseptic loosening of the prosthesis caused by wear-particle-induced osteolysis is a long-term complication and one of the most common reasons for the failure of joint implants. The primary cause of aseptic loosening of the prosthesis is overactive bone resorption caused by wear-particle-activated osteoclasts in both direct and indirect ways. Therefore, drugs that can inhibit differentiation and bone resorption of osteoclasts need investigation as a potential therapeutic strategy to prevent and treat peri-prosthetic osteolysis and thereby prolong the service life of the prosthesis.

Characterization of spatiotemporal patterns of soil water stable isotopes at an agricultural field.

Spatiotemporal variations in soil water content (SWC) and soil water stable isotopic compositions (SWSIC; H/H (δD) and O/O (δO)) provide critical information on elucidating land surface processes across scales. Meanwhile, little is known about the spatiotemporal characteristics of SWSIC and its driving factors. Therefore, it's necessary to improve tracer techniques of SWSIC by interpreting their spatiotemporal variability patterns as well as the correlations with other factors such as texture, soil depth and vegetation.