There is a correlation between long-term manganese (Mn) exposure and the Parkinson's-like disease (PD), with depression as an early symptom of PD. However, the direct relationship between Mn exposure and depression, and the mechanisms involved, remain unclear. We found that Mn exposure led to depressive-like behavior and mild cognitive impairment in mice, with Mn primarily accumulating in the cornu ammonis 3 (CA3) area of the hippocampus.
View Article and Find Full Text PDFObjectives: The aim of this study was to predict the risk of dental implant loss by clustering features associated with implant survival rates.
Materials And Methods: Multiple clinical features from 8513 patients who underwent single implant placement were retrospectively analysed. A hybrid method integrating unsupervised learning algorithms with survival analysis was employed for data mining.
Microorganisms can colonize to the surface of microplastics (MPs) to form biofilms, termed "plastisphere", which could significantly change their physiochemical properties and ecological roles. However, the biofilm characteristics and the deep mechanisms (interaction, assembly, and biogeochemical cycles) underlying plastisphere in wetlands currently lack a comprehensive perspective. In this study, in situ biofilm formation experiments were performed in a park with different types of wetlands to examine the plastisphere by extrinsic addition of PVC MPs in summer and winter, respectively.
View Article and Find Full Text PDFEnviron Sci Ecotechnol
September 2024
Organophosphate esters (OPEs) are increasingly recognized as pervasive environmental contaminants, primarily from their extensive application in flame retardants and plasticizers. Despite their widespread presence, the intricacies of OPE bioaccumulation within aquatic ecosystems remain poorly understood, particularly the environmental determinants influencing their distribution and the bioaccumulation dynamics across aquatic food chains. Here we show that water temperature plays a crucial role in modulating the dispersion of OPE in the aquatic environment of Poyang Lake.
View Article and Find Full Text PDFMunicipal sludge contains abundant amounts of carbon, with contents ranging from 14 % to 38 %. The various carbon-containing group compounds can be converted into beneficial products, but pollutants and greenhouse gases are also released through the municipal sludge pyrolysis process. Ascertaining the pathways by which carbon-containing group compounds is converted and transformed is crucial for addressing pollution concerns and promoting recycling.
View Article and Find Full Text PDFBackground: Lactate was a prognostic indicator for acute myocardial infarction (AMI) patients. However, the association between normalized lactate load, representing hypoxic burden over time, and in-hospital mortality remained uncertain.
Methods: The data for this study was obtained from the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2.
Background: The success of assisted pregnancy relies heavily on the effectiveness of the embryo transfer process. Currently, embryo transfer is typically conducted with the assistance of abdominal ultrasound.
Objective: The primary aim of this study was to evaluate the influence of targeted nursing interventions on the embryo transfer procedure, its impact on pregnancy outcomes, and the level of patient comfort concerning bladder management throughout the procedure.
Brusatol (Bru), a bioactive compound found in Brucea sumatrana, exerts antitumour effects on several malignancies. However, the role and molecular mechanism of Bru in squamous cell carcinoma of the oesophagus (ESCC) remain unclear. Here, we found that Bru decreased the survival of ESCC cells.
View Article and Find Full Text PDFRecurrent implantation failure (RIF) is a challenging scenario from different standpoints. This study aimed to investigate its correlation with the endometrial metabolic characteristics. Transcriptomics data of 70 RIF and 99 normal endometrium tissues were retrieved from the Gene Expression Omnibus database.
View Article and Find Full Text PDFCurr Top Med Chem
August 2023
Background: Lévl. et Van., Pamp.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
March 2023
Biochar (BC) has been widely applied in the remediation of chlorophenols (CPs) from contaminated sites in which the role and mechanisms of BC dissolved organic matter (BDOM), as a crucial component of BC, with CPs are largely unknown and thus need to be investigated. In this study, DOM was derived from peanut hulls (PDOM) and corn stalks (CDOM) as BC sources, and the interactions between PDOM/CDOM and 2,4,6-trichlorophenol (TCP) were analysed using excitation-emission matrix spectroscopy (EEM) in combination with multiple models. EEM combined with fluorescence region integration (EEM-FRI) indicated that humic-like materials were the major materials of both PDOM and CDOM (percentage fluorescence response R > 60%), and CDOM contained more protein- and fulvic-like materials than PDOM.
View Article and Find Full Text PDFParidis Rhizoma is a natural medicine with strong anti-tumor and anti-inflammatory activities. Our previous research have found that sp. C39, an endophytic fungus isolated from Dioscorea nipponica which contains the similar chemical components, significantly increased the steroidal saponins content of Paridis Rhizoma by fermentation.
View Article and Find Full Text PDFFulvic acid (FA) consists of various organic compounds that interact with metals in the aquatic environment. Interactions between subcomponents (FA, FA, FA, FA and FA) of FA and Cu(II) were investigated using fluorescence quenching titration by coupling differential fluorescence spectroscopy (DFS) and parallel factor analysis (PARAFAC). The material fluorescence intensities derived from FA subcomponents decreased with Cu(II) concentration increase, and stronger quenching was experienced at low Cu(II) concentrations.
View Article and Find Full Text PDFAim: To investigate the feasibility of predicting dental implant loss risk with deep learning (DL) based on preoperative cone-beam computed tomography.
Materials And Methods: Six hundred and three patients who underwent implant surgery (279 high-risk patients who did and 324 low-risk patients who did not experience implant loss within 5 years) between January 2012 and January 2020 were enrolled. Three models, a logistic regression clinical model (CM) based on clinical features, a DL model based on radiography features, and an integrated model (IM) developed by combining CM with DL, were developed to predict the 5-year implant loss risk.
J Anal Methods Chem
May 2022
This study conducted the solid fermentation process of using endophytic fungi C39 to determine the changes in the diosgenin concentration. The results revealed that endophytic fungi C39 could effectively biotransform the saponin components in . Moreover, the maximum increase in the diosgenin concentration reached 62.
View Article and Find Full Text PDFChlorophenols are difficult to degrade and biohazardous in the natural environment. This study demonstrated that humic acid (HA) could promote FeS activation of peroxymonosulfate (PMS) to degrade 2,4,6-trichlorophenol (TCP), the degradation efficiency of TCP was increased by 33%. The system of FeS-HA/PMS produced more reactive oxygen species, and •OH was the dominant ROS.
View Article and Find Full Text PDFErectile dysfunction (ED) and chronic periodontal disease (CPD) share mutual risk factors, and the incidence of ED is increasing among young adults. The relation of CPD and ED remains obscure due to inconsistent clinical evidence. This study aimed to further assess the relationship between CPD and ED using the Community Periodontal Index of Treatment Need (CPITN) and the International Index of Erectile Function (IIEF).
View Article and Find Full Text PDFPeriodontitis is a chronic infectious disease that causes inflammation and immune response and has an ultimate impact on the health of the whole body. Sirtuin6 (SIRT6) and Krüppel-like factor 5 (KLF5) have been reported to regulate the inflammatory response and play an important role in the development of periodontitis. LPS was adopted to induce periodontal ligament stem cells (PDLSCs) to construct a periodontitis cell model.
View Article and Find Full Text PDFFront Bioeng Biotechnol
January 2022
Early, high-throughput, and accurate recognition of osteogenic differentiation of stem cells is urgently required in stem cell therapy, tissue engineering, and regenerative medicine. In this study, we established an automatic deep learning algorithm, i.e.
View Article and Find Full Text PDFDue to its wide applications in tire and rubber products, carbon black (CB) implicates concerns on its safety during production, collection, and handling. Here we report that exposure CB, increases coagulation-thrombosis potential in a splenic extramedullary hemopoiesis (EMH)-dependent manner. Adult C57BL/6 mice are kept in whole-body inhalation chambers, and exposed to filtered room air (FRA) or CB for 28 consecutive days.
View Article and Find Full Text PDFPanax ginseng is one of the oldest and most generally prescribed herbs in Eastern traditional medicine to treat diseases. Several studies had documented that ginseng leaves have anti-oxidative, anti-inflammatory, and anticancer properties similar to those of ginseng root. The aim of this research was to forecast of the molecular mechanism of ginseng leaves on lung cancer by molecular docking and network pharmacology so as to decipher ginseng leaves' entire mechanism.
View Article and Find Full Text PDFJ Hazard Mater
August 2021
With the increased appreciation for the significance of noncoding RNAs (ncRNAs), the present research aimed to determine the role of competing endogenous RNA (ceRNA) in the process of particulate matter (PM) exposure-induced pulmonary damage. Alterations in messenger RNA (RNA), microRNA and long non-coding RNA (lncRNA) profiles of human bronchial epithelial (HBE) cells treated with PM were analyzed by microarray assays. Next, we identified that lncRNA taurine upregulated gene 1 (TUG1) acted as a competing endogenous RNA for microRNA-222-3p (miR-222-3p) and subsequently attenuated the inhibitory effect of miR-222-3p on CUGBP elav-like family member 1 (CELF1).
View Article and Find Full Text PDFModulating the structure of a photocatalyst at the molecular level can improve the photocatalytic efficiency and provides a guide for the synthesis of highly qualified photocatalysts. In this study, TiO was modified by various organic compounds to form different TiO-based hybrid photocatalysts. 1,10-Phenanthroline (Phen) is an organic material with delocalized π-conjugated systems.
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