[Study on the mechanism of autologous platelet-rich gel to treat the refractory diabetic dermal ulcers].

Objective: To investigate the mechanism of autologous platelet-rich gel (APG)in the treatment of refractory diabetic dermal ulcers.

Methods: After the treatment of refractory diabetic dermal ulcers with APG at 0, 3, 6, 9, 15 days, the protein levels of PDGF-BB, VEGF, IGF-1, EGF and TGF-beta1 in the granulation tissue were detected by ELISA, while the dimensions of ulcer area were measured at the same time.

Results: The areas of ulcers were obviously reduced at the third and fifteen day after APG treatment (P < 0.

[The preliminary application of autologous platelet-rich gel used to treat refractory diabetic dermal ulcer].

Objective: To assess the effectiveness and security of autologous platelet-rich gel (APG) in the treatment of refractory diabetic dermal ulcers.

Methods: Thirteen diabetic patients with refractory skin lesions were enrolled for this study, and APG was produced by platelet (PLT)-rich plasma (PRP) with thrombin and calcium gluconate. APG treatment consisted of wound dressed with APG, followed by topical washing and cleaning.