Upregulation of ITGB6 in primary palmar hyperhidrosis.

Background: The regulatory effect of integrin β6 (ITGB6) on sweat gland cells in primary palmar hyperhidrosis (PPH) remains unclear.

Objectives: This study investigated the involvement of ITGB6 in the pathogenesis of PPH.

Material And Methods: Sweat gland tissues were collected from PPH patients and healthy volunteers.

SiO/hyaluronic acid nanoparticles carry CaO, DOX and p53 plasmid to effectively achieve ion interference/chemical/gene multimodal therapy of lung cancer.

Monotherapy of lung cancer shows limited therapeutic effects due to its poorly targeted enrichment and low bioavailability. Using nanomaterials as carriers to form drug delivery systems has become a popular method to improve the targeting of anticancer drug therapy and patients' safety. However, the uniformity of the loaded drugs and the unsatisfactory effects are still the bottleneck in this field up to now.

Antagonist of Chrna1 prevents the pathogenesis of primary focal hyperhidrosis.

Background: Primary focal hyperhidrosis (PFH) is an autonomic neurological disease in which exocrine glands are oversecreted due to autonomic dysfunction of the sympathetic nervous system. Chrna1 promotes the pathogenesis of PFH. We aimed to check if downregulating of Chrna1 by cisatracurium could alleviate the symptoms of PFH.