How to Perform Laparoscopic Right Posterior Sectionectomy when the Right Intersectional Plane is not Always Flat.

Background: The right hepatic vein (RHV) is a crucial anatomical landmark, usually fully exposed during laparoscopic right posterior sectionectomy (LRPS). However, a discrepancy between the theoretical RHV-oriented plane and the actual right intersectional plane based on portal territory has been frequently observed in clinical practice. The potential reason for this discrepancy is branches of the Segment VI portal vein run on the ventral side of the RHV (Ventral-P6).

Cost-effective in-house-made whole blood materials for internal quality control in clinical flow cytometry analysis.

Internal quality control (IQC) is essential for ensuring the accuracy of results in clinical trials. However, there is a significant shortage of commercial quality control materials for IQC in flow cytometry. This study aimed to develop cost-effective in-house-made whole blood materials from clinically discarded samples to serve as IQC in clinical flow cytometry analysis.

Unveiling the industrial synergy optimization pathways in Beijing-Tianjin-Hebei urban agglomeration based on water-energy-carbon nexus.

Urban agglomerations play an increasingly important role in bolstering regional economic growth; meanwhile bring with substantial water and energy consumption and carbon emissions. Its sustainable development needs synergistic management of water-energy-carbon (WEC), which is vitally linked by industrial activities. Taken Beijing-Tianjin-Hebei (BTH) urban agglomeration in China, this study adopts material flow analysis to clarify WEC nexus footprint patterns of the urban agglomeration, initially develops a multi-regional dynamic synergistic development model to explore industrial optimization pathways for WEC system management from 2020 to 2035.

Anisotropic Microparticles with a Controllable Structure via Soap-Free Seeded Emulsion Polymerization.

Anisotropic particles have a wide range of applications in materials science such as emulsion stabilization, oil-water separation, and catalysis due to their asymmetric structure and properties. Nevertheless, designing and synthesizing large quantities of anisotropic particles with controlled morphologies continue to present considerable challenges. In this study, we successfully synthesized anisotropic microspheres using a soap-free seed emulsion polymerization method.

ZFP36L2 Is a Potential Prognostic Marker of IL1β Osteosarcoma.

Osteosarcoma stands as the predominant bone malignancy afflicting children and young adults. Despite strides in treatment, the enduring reality is that the long-term survival rates for patients grappling with recurrences and metastases linger at a mere 30%. This underscores the pressing demand for novel prognostic markers and therapeutic avenues to improve outcomes and offer hope to those battling this formidable disease.

Fundamentals of Viscoelastic Particle Focusing in Suddenly Expanded Microfluidic Channels.

Particles focusing in suddenly expanded microfluidic channels with viscoelastic biofluids have attracted increased interests due to the potential biomedical applications. In this work, three types of suddenly expanded channels were designed and employed for experiments. These suddenly expanded channels contained a certain number of triangular expansion structures on the sides of the straight channel to investigate the effect of secondary flow on particle viscoelastic focusing and we investigated particle focusing behavior in those three channels with 0.

MCoGCN-motif high-order feature-guided embedding learning framework for social link prediction.

Traditional social link prediction models primarily concentrate on the adjacency features of the network, overlooking the rich high-order structural information within. Therefore, the study of effective extraction and encoding of these high-order features, and their integration into prediction models, holds significant theoretical and practical value. To address this challenge, we propose a novel embedding learning framework guided by motif high-order features for social link prediction tasks.

Innovations in Microfluidics to Enable Novel Biomedical Applications.

As a new technique for precisely controlling micro-/nanoparticles and fluids at the microscale, microfluidics has been attracting increased interest in the fields of material science, medical diagnosis, biological research, and even soft robotics [...

A software tool for fabricating phantoms mimicking human tissues with designated dielectric properties and frequency.

Objectives: Dielectric materials play a crucial role in assessing and refining the measurement performance of dielectric properties for specific tasks. The availability of viable and standardized dielectric materials could greatly enhance medical applications related to dielectric properties. However, obtaining reliable phantoms with designated dielectric properties across a specified frequency range remains challenging.

Mechanisms of Differential Sensitivity to Ethanol-Induced Apoptosis in Mouse Spinal Cord at Different Developmental Stages-Akt/GSK Signaling and BAX.

The current study investigated differences in ethanol-induced apoptosis of spinal cord dorsal horn neurons at different developmental stages and the molecular mechanisms involved. A mouse ethanol intervention model was established on postnatal days 4, 7, and 12. Primary cells were derived from the spinal cord at postnatal day 4.

Efficacy of Intraoperative vs Preoperative Indocyanine Green Administration for Near-Infrared Cholangiography During Laparoscopic Cholecystectomy: An Open-Label, Noninferiority, Randomized Controlled Trial.

Background: Near-infrared fluorescence cholangiography improves the clinical effects of laparoscopic cholecystectomy. However, the administration of indocyanine green remains controversial. Both the intraoperative strategy (IS, 0.

Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis.

(PMC) is commonly used in clinical practice. While the adverse reactions of (RPM) are well-known, the potential adverse reactions of PMC are often neglected. This article aims to clarify the relationship between hepatotoxic components in PMC and its various producing areas.

Three-dimensional inertial focusing based impedance cytometer enabling high-accuracy characterization of electrical properties of tumor cells.

The differences in the cross-sectional positions of cells in the detection area have a severe negative impact on achieving accurate characterization of the impedance spectra of cells. Herein, we proposed a three-dimensional (3D) inertial focusing based impedance cytometer integrating sheath fluid compression and inertial focusing for the high-accuracy electrical characterization and identification of tumor cells. First, we studied the effects of the particle initial position and the sheath fluid compression on particle focusing.

FDA-approved small molecule kinase inhibitors for cancer treatment (2001-2015): Medical indication, structural optimization, and binding mode Part I.

The dysregulation of kinases has emerged as a major class of targets for anticancer drug discovery given its node roles in the etiology of tumorigenesis, progression, invasion, and metastasis of malignancies, which is validated by the FDA approval of 28 small molecule kinase inhibitor (SMKI) drugs for cancer treatment at the end of 2015. While the preclinical and clinical data of these drugs are widely presented, it is highly essential to give an updated review on the medical indications, design principles and binding modes of these anti-tumor SMKIs approved by the FDA to offer insights for the future development of SMKIs with specific efficacy and safety.

CMPK2 Promotes CD4 T Cell Activation and Apoptosis through Modulation of Mitochondrial Dysfunction in Systemic Lupus Erythematosus.

Systemic lupus erythematosus (SLE) is a classic autoimmune disease characterized by abnormal autoantibodies, immune complex deposition, and tissue inflammation. Despite extensive research, the exact etiology and progression of SLE remain elusive. Cytidine/uridine monophosphate kinase 2 (CMPK2), a mitochondrial nucleoside monophosphate kinase, has garnered attention for its potential involvement in the development of various diseases, including SLE, where it has been observed to be dysregulated in affected individuals.

Synergic effects and possible mechanism of emodin and stilbene glycosides on colorectal cancer.

Background: Polygonum multiflorum (PM) is a core herb that enhances immunity. It can also detoxify, reduce swelling, and intercept malaria. Its main components, emodin (EMD) and 2,3,5,4'-Tetrahydroxy stilbene-2-O-β-D-glucoside (stilbene glycoside, TSG), have good anti-cancer potential.

Epimedii Folium decoction ameliorates osteoporosis in mice through NLRP3/caspase-1/IL-1β signalling pathway and gut-bone axis.

Aim Of The Study: This study aimed to determine the effect of Epimedium brevicornu Maxim. (EF) on osteoporosis (OP) and its underlying molecular mechanisms, and to explore the existence of the "Gut-Bone Axis".

Material And Methods: The impact of EF decoction (EFD) on OP was evaluated using istopathological examination and biochemical assays.