Zero-Dimensional Plastic Phase Transition Iron-Based Compounds with High and Switchable SHG Responses.

Organic-inorganic hybrid materials have garnered significant interest due to their unique combination of phase transition characteristics, substantial entropy changes, simple preparation methods, and structural flexibility, making them promising candidates for applications in sensor technologies and data storage systems. In the present research, two plastic organic-inorganic hybrid phase transition materials: [CHNF]FeCl () and [CHNF]FeBr () were successfully synthesized by the H/F substitution strategy. Significant step-like dielectric changes were observed during the reversible phase transitions of (401 K) and (406 K).

Fermentation-enriched quinoa β-glucan ameliorates disturbed gut microbiota and metabolism in type 2 diabetes mellitus mice.

Quinoa β-glucan (QBG) has shown potential benefits in treating type 2 diabetes mellitus (T2DM); however, comprehensive evaluations of its effects remain limited. This study investigates the impact of QBG-derived from hot water extraction (Q-) and microbial fermentation enrichment (Q+)-on serum glucose levels, lipid profiles, appetite-regulating hormones, fecal short-chain fatty acids (SCFAs), and gut microbiota composition and function in streptozotocin/high-fat diet (STZ/HFD)-induced T2DM mice. The results indicate that QBG treatment significantly reduced fasting blood glucose, insulin levels, triglycerides (TG) and total cholesterol (TC), while concurrently increasing high-density lipoprotein cholesterol (HDLC) levels.

Deep Hypothermic Low Flow Results in Multiple Aspects of Neurological Deficits in Mice by eEF2 Hyperphosphorylation.

Postoperative neurological dysfunction is a common complication caused by deep hypothermia with cerebral hypoperfusion during aortic arch surgery, but the exact pathological changes and molecular mechanisms are not yet clear. In this study, we established an adult mouse model of deep hypothermic low flow (DHLF) to simulate the ischemic-reperfusion brain injury during aortic arch surgery. The DHLF-modeled mice showed significant neurological and cognitive dysfunction, accompanied by reduced dendritic spine density and increased glial cell activation in the hippocampus and cortex.

Loose Polyester Nanofiltration Membrane Designed with Hydroxyl-Ammonium for Efficient Dye/Salt Separation.

Efficient dye/salt separation poses a great challenge to nanofiltration (NF) membrane technology in the desalting sector of the dye synthesis industry. In this study, we fabricated a novel loose polyester NF membrane via an interfacial polymerization method using "hydroxyl-ammonium" biquaternary diethanolamine (MDET) and trimesoyl chloride. The molecular design of MDET provides a loose crosslinking network, showing high rejection of dyes and the passage of monovalent salt/divalent salt ions in the dye solution, exhibiting exceptional filtration efficiency with high selectivity.

Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L.

Nitrogen (N) is the driving factor for crop yield and quality, and more research is needed on the mechanisms of aged micro/nano plastics (MNPs) on N assimilation in edible crops. In this study, pot experiments were conducted to investigate the potential effect of aged polyethylene (PE) microplastic addition (particle sizes: 20 and 0.1 µm, addition levels: 0.

Comparative analysis of quality, structural, and flavor alterations in chestnuts (Castanea mollissima Blume) subjected to different thermal processing techniques.

This study investigated the effects of three thermal processing methods-steaming (100 °C), air frying (150 °C), and roasting (200 °C)-on the quality, structure, and flavor profiles of two chestnut (Castanea mollissima Blume) varieties, Dabanhong and Yanshanzaofeng. Nutritional composition, bioactive compounds, crystallinity, texture, color, and taste were assessed using gas chromatography-mass spectrometry (GC-MS), texture profile analysis (TPA), and an electronic tongue (E-tongue). Specifically, TPA effectively identified roasted chestnuts, while the E-tongue further distinguished steamed from air-fried chestnuts.

Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation.

Introduction: Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer, and effective therapeutic strategies are needed. Estrogen-related receptor alpha (ERRα) is considered a promising target for managing TNBC.

Objectives: Here, we aimed to screen natural products to find downregulator of ERRα and elucidate its mechanism of action.

Mechanistic Insights into CO Adsorption of LiSiO at High Temperature.

The development of materials with high adsorption capacity for capturing CO from industrial exhaust gases has proceeded rapidly in recent years. LiSiO has attracted attention due to its low cost, high capture capacity, and good cycling stability for direct high-temperature CO capture. Thus far, the CO adsorption mechanism of LiSiO is poorly understood, and detailed phase transformations during the CO adsorption process are missing.

Metagenome-assembled microbial genomes (n = 3,448) of the oral microbiomes of Tibetan and Duroc pigs.

Compared with leaner breeds, local Chinese pig breeds have distinct intestinal microbial, as determined by metagenomic techniques, and the interactions between oral microorganisms and their hosts are also gradually being clarified. However, the high host genome content means that few metagenome-based oral microbiomes have been reported. Here, we combined dilution-based metagenomic sequencing and binning approaches to extract the microbial genomes from the oral microbiomes of Tibetan and Duroc pigs.

Lead-grouped multi-stage learning for myocardial infarction localization.

The electrocardiogram (ECG) is a ubiquitous medical diagnostic tool employed to localize myocardial infarction (MI) that is characterized by abnormal waveform patterns on the ECG. MI is a serious cardiovascular disease, and accurate, timely diagnosis is crucial for preventing severe outcomes. Current ECG analysis methods mainly rely on intra- and inter-lead feature extraction, but most models overlook the medical knowledge relevant to disease diagnosis.

Towards healthy sleep environments: Ambient, indoor, and personal exposure to PM and its implications in children's sleep health.

The growing impact of climate change and escalating wildfire seasons has led to heightened ambient air pollution, potentially affecting children's sleep health. However, current epidemiological research often relies on outdoor weather data to model the environmental impacts on sleep health, potentially mischaracterizing the actual bedroom environment. To address these challenges, we conducted experiments to investigate the relationships among ambient, indoor, and personal exposure to PM concentrations and obstructive sleep apnea (OSA) in children.

Molecular regulation and domestication of parthenocarpy in cucumber.

Parthenocarpy is a pivotal trait that enhances the yield and quality of fruit crops by enabling the development of seedless fruits. Here we unveil a molecular framework for the regulation and domestication of parthenocarpy in cucumber (Cucumis sativus L.).

Study the effect of ATCC 14917 for caries prevention and anti-obesity.

Introduction: A complicated scenario where "multiple disease threats coexist and multiple health influencing factors are intertwined" is demonstrated by the fact that dental caries, obesity myopia and scoliosis have emerged as global public health issues. The problem of diseases co-existing in living things can be resolved by using probiotics. , has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.

(T6) Peptaibols Inhibiting the Growth and Inducing Pear Fruit Resistance in Its Infection.

Pear fruit brown rot, caused by , affects pear fruit yields and quality. The present study determined T6 (T6) peptaibols as a biological control alternative to synthetic fungicides and assessed its efficacy against through dual plate culture and surface spraying at different concentrations. T6 peptaibols effectively inhibited growth, achieving an 85.

3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models.

Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and advance respiratory pathophysiological research. The construction of biomimetic native airways and lungs with tissue-specific biological, mechanical, and configurable features remains challenging.

Novel Device for in Situ and Real-Time Detection of the Acidity of Ambient Aerosols: Laboratory Characterization and Ambient Measurements.

Aerosol acidity, defined as pH, is a critical property that influences the formation, evolution, and health and climate effects of atmospheric aerosol particles. Direct measurement of ambient aerosol pH, however, remains challenging for atmospheric scientists. Here, based on the method of colorimetric analysis on aerosol-loaded pH-indicator papers, we develop a new device that can achieve in situ and real-time measurement of the pH of ambient aerosol droplets at a fixed relative humidity of 90%.

Serum hemoglobin and albumin levels serve as prognostic predictors after adrenal metastasectomy.

Purpose: Adrenal metastasectomy is a common local treatment for adrenal metastases, with a lack of serum prognostic factors. Here, we identified the prognostic significance of preoperative hemoglobin and albumin levels in patients undergoing adrenal metastasectomy.

Materials And Methods: Data from 93 patients who underwent adrenal metastasectomy were assessed retrospectively.

Study on the Chemical Composition and Anti-Tumor Mechanisms of Fruit By-Products: Based on LC-MS, Network Pharmacology Analysis, and Protein Target Validation.

(Lour.) Skeels, commonly known as Wampee, are valued for their edible and medicinal qualities, yet their pericarp and seeds are often discarded, resulting in wasted resources. This study investigates the anti-tumor potential of these by-products, focusing on their chemical composition and underlying mechanisms of action.

One-Step Synthesis for Orn-Val with High Molecular Weight and Low Polydispersity by Ugi Four-Component Condensation.

Basic amino acid alternating copolymers exhibit exceptional antimicrobial properties and biosafety, yet their application is restricted by the complexity of the synthesis process and low molecular weight ( = 1000). In this study, we synthesized a basic amino acid alternating copolymer (Orn-Val) in only one step by the Ugi four-component condensation (Ugi'4CC), achieving high molecular weight ( = 20,000) and narrow polydispersity (PDI ≤ 1.10).

Tocilizumab for the management of corticosteroid-resistant GO combined with OMG: a case series.

Purpose: To highlight the safety and efficacy of tocilizumab (TCZ) in Graves' ophthalmopathy (GO) combined with ocular myasthenia gravis (OMG) patients refractory to steroids and cholinesterase inhibitor (CEI).

Methods: This was retrospective case series. We reviewed the health records of patients with GO combined with OMG, ten of whom were refractory to corticosteroids and CEI treatment and received intravenous injection of TCZ.

A Proprioceptive Janus Fiber with Controllable Multistage Segments for Bionic Soft Robots.

Smart fibers capable of integrating the multifunctionality of actuation and self-sensation into a single proprioceptive device have significant applications in soft robots and biomedicine. Especially, the achievement of self-sensing the movement patterns of different actuating segments in one fiber is still a great challenge. Herein, in this study, a fiber with the controllable Janus architecture is successfully proposed via an artful centrifugation-driven hierarchical gradient self-assembly strategy, which couples two functional components of piezoresistive carbon nanotubes and magnetic NdFeB nanoparticles into the upper and lower layers of this flexible fibrous framework with the porous sponge structure partially, respectively.