Publications by authors named "Nan Huang"

Chlorpyrifos (CLP) and deltamethrin (DTM) are among the most widely utilized organophosphate and pyrethroid insecticides globally. Their simultaneous presence in aquatic environments poses significant threats to fish health and challenges the sustainability of aquaculture practices. Despite their prevalence, the combined toxic effects of CLP and DTM on hook snout carp (Opsariichthys bidens Günther) remain insufficiently understood.

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HA/Fe composites were prepared by powder metallurgy. The effects of ball milling time, pressing pressure, and sintering temperature on the porosity and hardness of the composites were investigated, and their mechanical properties and biocompatibility were evaluated. The results show that as the ball milling time increases (30∼60min), the average particle size initially decreases and then increases (82.

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Objective: In this cross-sectional study including patients with type 2 diabetes mellitus (T2DM) we aimed to explore the relationship between serum 25-hydroxy vitamin (25(OH)D) level and liver steatosis and fibrosis in the Chinese population.

Methods: Patients visiting 16 clinical centers with T2DM were recruited. Their liver steatosis and fibrosis status were then assessed using elastography.

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Background: The literature contains exceedingly limited reports on chromosome 10p15.3 microdeletions. In the present study, two cases of fetuses with pure terminal 10p15.

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Disulfidptosis is a newly discovered method of cell death. However, no studies have fully elucidated the role of disulfidptosis-related genes (DSRGs) in acute myocardial infarction (AMI). The potential role of DSRGs in AMI was analyzed through a comprehensive bioinformatics approach.

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Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Macrophages are abundant in the tumor microenvironment, making them an attractive target for therapeutic intervention. While current immunotherapies, including immune checkpoint inhibition (ICI) and chimeric antigen receptor T (CAR-T) cells, have shown limited efficacy in pancreatic cancer, a novel approach involving chimeric antigen receptor macrophages (CAR-M) has, although promising, not been explored in pancreatic cancer.

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An intriguing P-H insertion of arylhalodiazirines with -phosphorus oxides under ultraviolet-light irradiation is described. This methodology provides an efficient and straightforward route to the construction of a variety of αhalophosphorus oxides in good yields (≤95%), which represents a unique example of P-H insertion of αhalocarbenes for C-P bond formation. The metal-free protocol features the advantages of mild reaction conditions, high atom economy, and environmental friendliness.

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Article Synopsis
  • * The most common genotype found was Southeast Asian deletion (--)/αα, while a rare genotype HKαα/-- was also identified; individuals with thalassemia had milder anemia symptoms compared to those with iron deficiency or overload.
  • * The research indicated significant differences in hematological parameters based on age and gender in patients, with older individuals and males generally showing higher hemoglobin and RBC levels than their counterparts.
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Poor wound healing in diabetics is primarily caused by persistently high levels of inflammation and recurrent bacterial infections. The catalytic therapy technique based on nanozyme medicine has emerged as a beacon of hope for patients with diabetic wounds. However, the use of a single-atom nanozyme may still have limitations, including nanozyme burst release, immunological clearance and insufficient antibacterial activity.

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Background: Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide, with death rates increasing by approximately 2-3% per year. The high mortality and poor prognosis of HCC are primarily due to inaccurate early diagnosis and lack of monitoring when liver transplantation is not feasible. Fatty acid (FA) metabolism is a critical metabolic pathway that provides energy and signaling factors in cancer, particularly in HCC, and promotes malignancy.

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  • A comprehensive study conducted in Wuhan, China, analyzed anaphylaxis cases among inpatients over 21 years, revealing an incidence rate of 16.92 per 100,000 individuals, with a stable but gradually rising trend.
  • The majority of anaphylaxis cases were triggered by drugs, particularly antibiotics (38.4%), with specific triggers varying by age group, showing that 13.5% of cases had unknown causes.
  • Treatment with epinephrine was administered in only 36.0% of cases, yet its use has been increasing, leading to a low mortality rate of 1.6%, which has shown a consistent downward trend.
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Melatonin is a neuroendocrine hormone that exerts protective effects on the heart. Increasing evidence suggests that macrophage M2-type polarization improves myocardial regeneration and repair. Therefore, this study investigated whether melatonin ameliorates dilated cardiomyopathy (DCM) by modulating M2-type polarization.

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The giant magnetoresistance effect in two-dimensional (2D) magnetic materials has sparked substantial interest in various fields; including sensing; data storage; electronics; and spintronics. Their unique 2D layered structures allow for the manifestation of distinctive physical properties and precise performance regulation under different conditions. In this review, we present an overview of this rapidly developing research area.

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Proteins with intrinsic cell permeability that can access intracellular targets represent a promising strategy for novel drug development; however, a general design principle is still lacking. Here, we established a library of 46,678 de novo-designed mini-proteins and performed cell permeability screening via phage display. Analyses revealed a characteristic neighboring distribution of positive charges across helices among enriched mini-proteins of CPP7, CPP11, CPP55, CPP109 and CPP112.

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Article Synopsis
  • * The study analyzed regional differences in water quality standards based on factors like climate, social attributes, and aquatic life, highlighting the need for more adaptable and effective standards.
  • * It identifies key scientific questions and future research directions necessary for developing regional water quality standards, such as determining effluent dilution methods and evaluating impactful water quality indicators.
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Thrombosis associated with implants can severely impact therapeutic outcomes and lead to increased morbidity and mortality. Thus, developing blood-contacting materials with superior anticoagulant properties is essential to prevent and mitigate device-related thrombosis. Herein, we propose a novel single-molecule multi-functional strategy for creating blood-compatible surfaces.

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Article Synopsis
  • Scientists studied a large group of people in Southeast China to learn about thalassemia and hemoglobin (Hb) variants using a special testing method called third-generation sequencing (TGS).
  • They tested over 6,000 people and found that about 2,400 had gene mutations related to thalassemia, including some unique ones that hadn’t been seen before in that area.
  • The results from this study can help doctors understand thalassemia better and improve genetic testing for people with these conditions.
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  • Triazophos (TRI) and fenvalerate (FEN) are common pesticides that coexist in water environments, potentially harming aquatic species such as fish.
  • A study exposing parental zebrafish to TRI, FEN, and their mixture for 60 days revealed that these pesticides can negatively affect the offspring's biological processes, even when the offspring aren't directly exposed.
  • The findings suggest that exposure to pesticide mixtures leads to significant changes in gene expression related to health and development in fish, highlighting the need for further research on the impacts of these chemicals on aquatic vertebrates.
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Background: The incidence of muscle atrophy or sports injuries is increasing with time and population aging, thereby attracting considerable attention to muscle generation research. Muscle satellite cells, which play an important role in this process, lack comprehensive literature regarding their use for muscle regeneration. Hence, this study aimed to analyze the hotspots and trends in satellite cell research from 2010 to 2023, providing a reference for muscle regeneration research.

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Purpose: Insulin resistance is associated with kidney impairment in patients with type 2 diabetes mellitus (T2DM). The triglyceride glucose-body mass index (TyG-BMI), which combines the TyG index with body mass index (BMI), has received significant attention as a tool for evaluating insulin resistance. Thus, the aim of this study was to explore the association between TyG-BMI and kidney impairment in patients with type 2 diabetes mellitus (T2DM).

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