Circular RNA hsa_circ_0004650 Enhances 5-Fluorouracil Resistance in Gastric Cancer Sponging miR-145-5p.

Background/aim: Chemotherapy based on 5-fluorouracil (5-Fu) is the first-line treatment for advanced gastric cancer (GC) patients. Importantly, 5-Fu resistance is recognized as a major obstacle for the successful treatment of GC. Circular RNAs (circRNAs) are non-coding RNAs involved in the pathogenesis of GC.

Acetoin Promotes Plant Growth and Alleviates Saline Stress by Activating Metabolic Pathways in Lettuce Seedlings.

Acetoin is a volatile organic compound, which is a class of metabolites produced by plant growth-promoting rhizobacteria. The mechanisms underlying plant growth promotion by acetoin and its potential to induce saline stress tolerance in plants are poorly understood. Lettuce ( L.

A multi-antigen vaccinia vaccine broadly protected mice against SARS-CoV-2 and influenza A virus while also targeting SARS-CoV-1 and MERS-CoV.

Introduction: Coronaviruses and influenza viruses are significant respiratory pathogens that cause severe disease burdens and economic losses for society. Due to their diversity and evolution, vaccines typically require periodic updating to remain effective. An additional challenge is imposed by the possible coinfection of SARS-CoV-2 and influenza, which could increase disease severity.

Brain Resident Ly6C Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis.

Adult hippocampal neurogenesis (AHN) is crucial to various brain functions. Neurodegeneration, neuroinflammation and stress can impair AHN, contributing to the development of neurological and psychiatric disorders. Stress is known to extensively affect both the brain and peripheral immune system.

Modulating Ion Behavior by Functional Nanodiamond Modified Separator for High-Rate Durable Aqueous Zinc-Ion Battery.

Aqueous zinc-ion batteries (AZIBs) have garnered widespread attention due to their promising development and application prospects. However, progress of AZIBs has been hindered by zinc (Zn) dendrites and side reactions at the electrode-electrolyte interface (EEI). In particular, the large and uneven pores of commercial glass fiber (GF) separators lead to nonuniform Zn transport, which causes side reactions.

Constructing a Metal-Organic Frameworks-Based Long-Acting Sequential Release System for the Treatment of Alzheimer's Disease.

Due to the unclear pathogenesis of Alzheimer's disease (AD) and the lack of a completely cured medication, AD patients need to take medication in order and on time every day all one's life, which is difficult for severe memory impairment patients to strictly follow on time. Traditional AD drug carriers, such as sugar coating and capsules, rely on dissolution or fragmentation to achieve drug release, which lacks the interaction between drug molecules and carriers, thus they cannot achieve sufficient long-acting and sequential drug release. Herein, Mn-MOF-74, which ligand structure is similar to two antioxidants dihydroquercetin (DHQ) and resveratrol (Res) is chosen as the carrier.

Microcirculatory parameters as risk factors for predicting progression of posterior staphyloma in highly myopic eyes: a case-control study.

Background: To assess the rate of macular blood flow decreasing in adults with and without posterior staphyloma (PS) using optical coherence tomography angiography (OCTA) and to identify risk factors associated with PS progression.

Methods: This longitudinal case-control study enrolled 122 eyes of 122 patients-64 patients with PS (PS group) and 58 patients without PS (NPS group). Participants underwent OCTA and clinical examinations at least twice, and those followed for at least one year were included in the analysis.

Efficient Ion Screening Boosted by MOF/COF Bilayer Membrane Through Multiple Separation Mechanisms.

Porous organic frameworks (POFs), including metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), have drawn attention as ion-selective materials due to their well-defined channels and functional sites. However, their individual limitations require novel approaches to maximize their potential. In this study, a hybrid bilayer membrane combining MOFs and COFs on a nylon substrate via consecutive liquid-liquid interface polymerization is developed.

Ruminococcus gnavus in the gut: driver, contributor, or innocent bystander in steatotic liver disease?

The human gut microbiome plays a crucial role in regulating intestinal and systemic health, impacting host immune response and metabolic function. Dysbiosis of the gut microbiome is linked to various diseases, including steatotic liver diseases. Metabolic dysfunction-associated steatotic liver disease (MASLD), a chronic liver disease characterized by excess hepatic lipid content and impaired metabolism, is the leading cause of liver disease worldwide.

High-fidelity surface reconstruction using complementary colorimetry-encoded fringe projection profilometry.

To solve the challenging issue of uneven reflectance of high-fidelity surface, this paper proposes a three-dimensional (3D) shape measurement method based on surface adaptation complementary colorimetry-encoded fringe projection profilometry. A complete complementary hue extraction method simulates the retina stimulation to establish the complementary conversion relationship between the projected and collected colors of the measurement system. On this basis, a surface reflectance adaptation fringe pattern encoding strategy is proposed to measure the high-fidelity surfaces.

3D shape measurement method for high-reflective surface based on a color camera.

Fringe projection profilometry (FPP) has been widely utilized in many fields due to its non-contact, high accuracy, high resolution and full-field measurement capabilities. However, the limited dynamic range of the camera sensor can result in overexposure of high-reflective parts in industrial production measurement. To effectively solve the above issue, this paper proposes a 3D shape measurement method for the high-reflective surface based on a color camera.

De novo design of Na-activated lipopeptides with selective antifungal activity: A promising strategy for antifungal drug discovery.

In recent years, invasive fungal infections have posed a significant threat to human health, particularly due to the limited availability of effective antifungal medications. This study responds to the urgent need for powerful and selective antifungal agents by designing and synthesizing a series of lipopeptides with lipoylation at the N-terminus of the antimicrobial peptide I6. Compared to the parent peptide I6, lipopeptides exhibited selective antifungal efficacy in the presence of Na.

Macrophage LRRK2 hyperactivity impairs autophagy and induces Paneth cell dysfunction.

polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's disease (CD) lead to LRRK2 kinase hyperactivity and suppress autophagy. This connection suggests that LRRK2 kinase inhibition, a therapeutic strategy being explored for Parkinson's disease, may also benefit patients with CD. Paneth cell homeostasis is tightly regulated by autophagy, and their dysfunction is a precursor to gut inflammation in CD.

Jet mixing optimization using a bio-inspired evolution of hardware and control.

Jet mixing is a critical factor in various engineering applications, influencing pollutant dispersion, chemical processes, medical treatments, and combustion enhancement. Hitherto, jet mixing has typically been optimized by either passive or active control techniques. In this experimental study, we combine simultaneous optimization of active control with 12 inward-pointing minijets and a tuneable nozzle exit shape commanded by 12 stepper motors.

Menaquinone-4 Alleviates Sepsis-Associated Acute Lung Injury via Activating SIRT3-p53/SLC7A11 Pathway.

Background: Sepsis-associated acute lung injury (SI-ALI) is triggered by various direct or indirect noncardiogenic factors affecting the alveolar epithelium and capillary endothelial cells. Menaquinone-4 (MK-4), a major component of vitamin K, plays a crucial role as an antioxidant by effectively neutralizing reactive oxygen species (ROS) and safeguarding critical biomolecules from oxidative harm within cells. However, the specific mechanisms and clinical implications of MK-4 in SI-ALI are unclear and require further study.

Electrochemiluminescence Reveals the Structure-Catalytic Activity Relationship of Heteroatom-Doped Carbon-Based Materials.

Heteroatom doping can change the chemical environment of carbon-based nanomaterials and improve their catalytic performance. Exploring the structure-catalytic activity relationship of heteroatom-doped carbon-based materials is of great significance for studying catalytic mechanisms and designing highly efficient catalysts, but remains a significant challenge. Recently, reactive oxygen species (ROS)-triggered electrochemiluminescence (ECL) has shown great potential for unveiling the mechanism by which heteroatom-doped carbon-based materials catalyze the oxygen reduction reaction (ORR), owing to the high sensitivity of these materials to the properties of the electrode surface.

From Lab to Life: Self-Powered Sweat Sensors and Their Future in Personal Health Monitoring.

The rapid development of wearable sweat sensors has demonstrated their potential for continuous, non-invasive disease diagnosis and health monitoring. Emerging energy harvesters capable of converting various environmental energy sources-biomechanical, thermal, biochemical, and solar-into electrical energy are revolutionizing power solutions for wearable devices. Based on self-powered technology, the integration of the energy harvesters with wearable sweat sensors can drive the device for biosensing, signal processing, and data transmission.

Identification of a T-box transcription factor TBX2 and its negative regulatory role in melanin production in the Pacific oyster Crassostrea gigas.

Oyster shells exhibit varying color patterns-black, white, or black and white striations-attributable to differences in melanin content and distribution. In this study, we identified a new homolog of TBX2, a member of the T-box transcription factor family, in the Pacific oyster (Crassostrea gigas) named CgTBX2. The mRNA expression of CgTBX2 was higher in tissues from white-shelled oysters than in those from black-shelled oysters.

Foxp3 regulatory T cells reside within the corneal epithelium and co-localize with limbal stem cells.

In this study we investigated the presence of resident Foxp3 regulatory T cells (Tregs) within the cornea and assessed the role of resident Tregs in corneal epithelial wound healing. Using a mouse model, we showed that in the steady state Foxp3Tregs are either in close proximity or co-localize with ABCG2 limbal stem cells. We also showed that these Tregs reside within the epithelial layer and not the corneal stroma.

Myosin Vb Traffics P-Glycoprotein to the Apical Membrane of Intestinal Epithelial Cells.

Background & Aims: The xenobiotic efflux pump P-glycoprotein is highly expressed on the apical membrane of the gastrointestinal tract, where it regulates the levels of intracellular substrates. P-glycoprotein is altered in disease, but the mechanisms that regulate the levels of P-glycoprotein are still being explored. The molecular motor myosin Vb (Myo5b) traffics diverse cargo to the apical membrane of intestinal epithelial cells.

Interface potential-induced natural antioxidant mimic system for the treatment of Alzheimer's disease.

Although the pathogenesis of Alzheimer's disease (AD) is still unknown, the molecular pathological phenomena is clear, mainly due to mitochondrial dysfunction and central nervous system inflammation caused by imbalanced antioxidant capacity and synaptic dysfunction, so antioxidant therapy is still the preferred treatment for AD. However, although antioxidant enzymes have high catalytic efficiency, the substrate spectrum is narrow; Antioxidants have wider range of effects, but their efficiency is low. Since the antioxidant defense system in high-grade organisms is composed of both enzymatic and non-enzymatic systems, therefore we synthesized a metal-organic framework (MOF) with superoxide dismutase activity, and depending on the interface potential effect, curcumin was loaded to construct a synergistic antioxidant treatment system.

Design and optimization of pore structure in three-dimensional micro-nano hierarchical SnO supercapacitor electrodes for enhanced ion diffusion.

This paper introduced a novel continuous electrochemical synthesis strategy to address the challenges of slow ion/electron transport rates and low electrode reaction efficiency in Sn-based electrode materials. This approach leveraged the induction and confinement of bubble templates to assist atoms deposition, generating micron-sized tin skeletons. Subsequently, these skeletons were transformed into a secondary nanoporous structure through dissolution-deposition etching effects.

Biomimetic Peptide Nanonets: Exploiting Bacterial Entrapment and Macrophage Rerousing for Combatting Infections.

The alarming rise in global antimicrobial resistance underscores the urgent need for effective antibacterial drugs. Drawing inspiration from the bacterial-entrapment mechanism of human defensin 6, we have fabricated biomimetic peptide nanonets composed of multiple functional fragments for bacterial eradication. These biomimetic peptide nanonets are designed to address antimicrobial resistance challenges through a dual-approach strategy.