Publications by authors named "Namratha Prabhu"
Article Synopsis
- Acute encephalitis syndrome (AES) in children is a major health issue in India, and this study evaluates the role of inflammatory mediators and neurofilament (NfL) levels in differentiating the causes, understanding disease severity, and predicting outcomes in AES.*
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- The research analyzed serum and cerebrospinal fluid (CSF) samples from 62 children with AES, finding that markers differed significantly among scrub typhus, viral infections, and COVID-related multisystem inflammatory syndrome (MIS-C), with specific levels of cytokines revealing patterns that aid in diagnosis.*
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- The study concluded that certain serum markers could effectively differentiate between scrub typhus and other types of AES, and higher levels of certain
Emerg Infect Dis
April 2023
Article Synopsis
- - Scrub typhus, caused by Orientia tsutsugamushi, is recognized as a significant contributor to acute encephalitis syndrome (AES) in northern India, and this study examined its impact in southern India by diagnosing 376 children with AES.
- - Among the children tested, scrub typhus was diagnosed in 87 (23%), with varying degrees of association to AES: confirmed in 16, probable in 55, and possible in 16 cases.
- - The study found that IgM detection in cerebrospinal fluid (CSF) is a reliable diagnostic tool, showing a 93% sensitivity and an 82% specificity, underscoring the need for routine testing for scrub typh
