Publications by authors named "Namon Hirun"

Article Synopsis
  • Androgenetic alopecia (AGA) is a hair loss condition linked to the hormone dihydrotestosterone (DHT), and the study focuses on enhancing caffeine delivery to hair follicles to counteract its effects.
  • Researchers developed a new drug delivery system using caffeine-loaded hollow mesoporous silica nanoparticles coated with ultradeformable liposomes (ULp-Caf@HMSNs), which improve caffeine's ability to penetrate skin and reduce hair loss.
  • Results showed that this new system is non-toxic to hair follicle cells, increases cell viability, and effectively reduces harmful oxidative stress in cells affected by DHT, making it a promising alternative to existing treatments like minoxidil.
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The aqueous solution of binary mixtures of amphiphilic copolymers is a potential platform for fabricating mixed polymeric micelles for pharmaceutical applications, particularly in developing drug delivery depots for a poorly water-soluble compound. This study fabricated and investigated binary mixtures of poloxamer 403 (P403) and poloxamer 407 (P407) at varying P403:P407 molar ratios to develop a vehicle for the poorly water-soluble compound, using ibuprofen as a model drug. The cooperative formation of mixed micelles was obtained, and the solubility of ibuprofen in the binary mixtures was enhanced compared to the solubility in pure water and an aqueous single P407 solution.

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  • This study focused on creating H-K4M hydroxypropyl methylcellulose (HPMC) films with nanostructured lipid carriers (NLCs) that are loaded with the drug furosemide, using techniques like hot homogenization and ultrasonic probes to manufacture and size the NLCs.
  • A Box-Behnken design was used to explore how three factors—H-K4M concentration, surfactant concentration, and mixing speed—affected the physical and chemical properties of both the NLCs and the resulting films.
  • Results indicated that the furosemide-loaded NLCs had small particle sizes and a varied polydispersity index, while the films showed good thickness, weight,
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Fluconazole (FZ) is a potential antifungal compound for treating superficial and systemic candidiasis. However, the use of conventional oral drug products has some limitations. The development of buccal film may be a potential alternative to oral formulations for FZ delivery.

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A pullulan (Pul)-derivative hydrogel was developed by introducing methacrylate (MA) groups and β-cyclodextrin (βCD) to form a Pul-βCD-MA hydrogel by UV cross-linking. The MA was expected to improve the hydrogel's mechanical properties and the βCD to increase the solubility of curcumin. Pul-βCD-MA was successfully synthesized, as confirmed by the H NMR and FTIR spectra.

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The combination of the thermoresponsive polymer and protein has demonstrated great promise in its applications in drug delivery and tissue engineering fields. This study described the impact of bovine serum albumin (BSA) on the micellization and sol-gel transition behaviors of poloxamer 407 (PX). The micellization of aqueous PX solutions with and without BSA was examined using isothermal titration calorimetry.

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Article Synopsis
  • The study developed a 3D-printed bento box model (BB) designed to release the drug propranolol hydrochloride (PNL) in a controlled manner using USP dissolution guidelines.
  • The BBs were created with polyvinyl alcohol and varied in infill percentages and wall thickness, impacting their physical properties and drug release capabilities.
  • Results indicated that some formulations of the 3D-printed BBs successfully met the drug release standards set by USP, suggesting a promising application for improved drug delivery in the pharmaceutical field.
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  • The research examined how different hydroxypropyl methylcellulose (HPMC) types in matrix tablets influence the release of propranolol hydrochloride (PNL), a drug ideal for studying extended-release formulations.
  • Using methods like FTIR, PXRD, and DSC, the study confirmed the compatibility of PNL with the excipients.
  • Results showed that HPMC tablets sustained PNL release for over 12 hours, with release mechanisms indicated by values between 0.476 and 0.497, suggesting an anomalous transport process.
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Herein, thermosensitive blends of poloxamer 407 (P407)/poloxamer 188 (P188)/polycarbophil (PCB) were developed in terms of maximized content of PCB (a mucoadhesive polymer) and desired temperature-dependent rheological properties of the blends as in situ gelling matrices. Maximizing PCB content while achieving the preferable rheological characteristics was accomplished through the Box-Behnken design. The quantitative effect of the polymer composition in the blends on the thermosensitive characteristics was evaluated using the fitted design model and the corresponding surface plots.

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Oxyresveratrol (OXY) exhibits poor bioavailability due to its low solubility. Cocrystals are effective in improving solubility of OXY. In this study, principal component analysis (PCA) was employed for coformer selection using 5 variables (solubility parameter, logP, hydrogen bonding acceptor, hydrogen bonding donor and molecular volume).

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Thermosensitive hydrogels are of great interest for in situ gelling drug delivery. The thermosensitive vehicle with a gelation temperature in a range of 30-36°C would be convenient to be injected as liquid and transform into gel after injection. To prepare novel hydrogels gelling near body temperature, the gelation temperature of poloxamer 407 (PX) were tailored by mixing PX with poly(acrylic acid) (PAA).

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Novel hydrogels of methylcellulose (MC) with gallic acid (GA) and NaCl were developed for an in situ gel-forming delivery system. Plain MC and GA/NaCl/MC were characterized using micro-differential scanning calorimetry (micro-DSC), rheological and turbidity methods. The gelation temperatures of MC were reduced to body temperature with adding GA/NaCl.

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Novel gels were prepared by blending β-cyclodextrin and polyethyleneglycol (PEG) in the presence of K2CO3. The objective of this study was thus to characterize the gels using rheology, modulated temperature differential scanning calorimetry (MTDSC), turbidity measurements, and hot stage microscopy, and then investigate the potential use of the gel for topical drug delivery. Two types of supramolecular gels, GelL and GelH were prepared at a low temperature (below 50 °C) and at a high temperature (above 70 °C), respectively.

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Background: Tamarind seed xyloglucan (TSX) is generally used for drug delivery systems. Gallic acid (GA) possesses various pharmacological activities. It has a good solubility and bioavailability but short half-life.

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Gallic acid (3,4,5-trihydroxybenzoic acid, GA) has many possible conformers depending on the orientations of its three OH and COOH groups. The biological activity of polyphenolic compounds has been demonstrated to depend on their conformational characteristics. Therefore, experimental FTIR and theoretical studies of the GA-solvent clusters were performed to investigate the possible most favored conformation of GA.

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In the title compound, C(7)H(6)O(5), the three hy-droxy groups on the ring are oriented in the same direction. There are two intra-molecular O-H⋯O hydrogen bonds in the ring. In the crystal, there are several inter-molecular O-H⋯O hydrogen bonds and a short contact of 2.

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Article Synopsis
  • A novel gel system combining tamarind seed xyloglucan (TSX) and Eriochrome Black T (EBT) showed shear-thinning behavior, with viscosity increasing as EBT concentrations rose.
  • Mixtures at specific EBT concentrations formed weak gels that remained sol at room temperature but turned into gels when heated to body temperature, allowing for effective drug release.
  • The EBT-TSX systems demonstrated sustained EBT release, indicating their potential as injectable implants for targeted treatment of solid malignant tumors.
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